HC≡C-CH2-PEG3-SH
HC≡C-CH2-PEG3-SH Basic information
- Product Name:
- HC≡C-CH2-PEG3-SH
- Synonyms:
-
- HC≡C-CH2-PEG3-SH
- Propargyl-PEG3-SH
- Ethanethiol, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
- CAS:
- 1412905-18-0
- MF:
- C9H16O3S
- MW:
- 204.29
- Mol File:
- 1412905-18-0.mol
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HC≡C-CH2-PEG3-SH Chemical Properties
- Boiling point:
- 286.2±30.0 °C(Predicted)
- Density
- 1.053±0.06 g/cm3(Predicted)
- pka
- 9?+-.0.10(Predicted)
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HC≡C-CH2-PEG3-SH Usage And Synthesis
Biological Activity
Propargyl-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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