HC≡C-CH2-PEG3-SH Chemical Properties

Boiling point:

286.2±30.0 °C(Predicted)

Density 

1.053±0.06 g/cm3(Predicted)

pka

9?+-.0.10(Predicted)

HC≡C-CH2-PEG3-SH Usage And Synthesis

Uses

Propargyl-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-SH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological Activity

Propargyl-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HC≡C-CH2-PEG3-SH(1412905-18-0)Related Product Information

• 2-[2-(PROP-2-YNYLOXY)ETHOXY]ETHAN-1-OL
• propargyl-PEG3-Acid