Propargyl-PEG10-amine Chemical Properties

Boiling point:

545.5±45.0 °C(Predicted)

Density 

1.079±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, sealed storage, away from moisture and light

form 

Liquid

pka

8.74±0.10(Predicted)

color 

Colorless to light yellow

Propargyl-PEG10-amine Usage And Synthesis

Description

Propargyl-PEG10-amine is a PEG reagent that is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group enables Click Chemistry reactions with azide-bearing compounds or biomolecules; copper catalyst is required.

Uses

Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG10-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.

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