Propargyl-PEG2-t-butyl ester Chemical Properties

Boiling point:

290.5±20.0 °C(Predicted)

Density 

1.007±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

color 

Colorless to light yellow

Propargyl-PEG2-t-butyl ester Usage And Synthesis

Description

Propargyl-PEG2-t-butyl ester is a PEG linker that enables Click Chemistry reactions with azide-bearing compounds or biomolecules; copper will be required for catalyzation. Under acidic conditions, the t-butyl group can be removed.

Uses

Propargyl-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Propargyl-PEG2-t-butyl ester(1807503-80-5)Related Product Information

• 3-(2-Methoxyethoxy)prop-1-yne
• INDEX NAME NOT YET ASSIGNED
• 3-(2-(2-Azidoethoxy)ethoxy)prop-1-yne
• Propargyl-PEG2-Maleimide
• Propargyl-PEG2-methylamine