Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Chemical Properties

Boiling point:

389.8±50.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Solid

color 

White to off-white

Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Usage And Synthesis

Uses

Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological Activity

Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.

Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester(2512228-06-5)Related Product Information

• Propargyl-PEG2-t-butyl ester
• 3-(2-(2-Azidoethoxy)ethoxy)prop-1-yne
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• Propargyl-PEG2-methylamine
• 3-(2-Methoxyethoxy)prop-1-yne
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• :4',5'-bis(4-carboxyphenyl)-3',6'-dimethyl-[1,1':2',1''-terphenyl]-4,4''-dicarboxylic acid
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