4-(4-Fluorobenzoyl)piperidine hydrochloride Chemical Properties

Melting point:

222-224°C

Density 

1.31g/cm3 at 20℃

vapor pressure 

0-0Pa at 20-25℃

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Water (Slightly)

form 

Solid

color 

Pale Tan

Sensitive 

Hygroscopic

InChI

InChI=1S/C12H14FNO.ClH/c13-11-3-1-9(2-4-11)12(15)10-5-7-14-8-6-10;/h1-4,10,14H,5-8H2;1H

InChIKey

GPKDBZQZPNOBGM-UHFFFAOYSA-N

SMILES

C1(C=CC(F)=CC=1)C(=O)C1CCNCC1.Cl

LogP

-1.1 at 20℃ and pH7

CAS DataBase Reference

25519-78-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C,Xn

Risk Statements 

36/37/38-20/21/22-22

Safety Statements 

26-36/37/39-22

Hazard Note 

Irritant

HazardClass 

IRRITANT, MOISTURE SENSITIVE, CORROSIVE

HS Code 

2933399990

MSDS

• Language:English Provider:ALFA

4-(4-Fluorobenzoyl)piperidine hydrochloride Usage And Synthesis

Uses

4-(4-Fluorobenzoyl)piperidine, HCl

Uses

4-(4-Fluorobenzoyl)piperidine hydrochloride is a piperidnyl derivative used in the preparation of antiarrhythmics as well as α1-adrenoceptor and S2-receptor antagonists for circulatory diseases.

Synthesis

A solution of 70.6 of 1-acetyl-4-(4-fluorobenzoyl)piperidine in 200 ml of 6N HCl is refluxed for 2 hours. The cooled solution is extracted twice with ether, the aqueous solution basified with sodium hydroxide and then extracted with benzene. The benzene extracts are dried, filtered and the filtrate is concentrated under reduced pressure. The residual oil is dissolved in ether and HCl gas is bubbled into the solution with stirring. The salt is collected by filtration, washed with ether and dried. The salt is recrystallized from isopropanol to give the solid product of 4-(4-fluorobenzoyl)piperidine hydrochloride, mp 222°-224° C.

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