Methyl 2-methyl-3-nitrobenzoate Chemical Properties

Melting point:

62-65 °C (lit.)

Boiling point:

286.6±20.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in methanol.

form 

Solid

color 

Pale Beige

BRN 

1964020

CAS DataBase Reference

59382-59-1(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29163990

MSDS

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Methyl 2-methyl-3-nitrobenzoate Usage And Synthesis

Description

Methyl 2-methyl-3-nitrobenzoate is an important organic synthetic material and pharmaceutical intermediate compound. It can be used for the preparation of the anticancer drug lenalidomide as well as other organic compounds (e.g., indole-4-carboxylic acid methyl ester, 5-nitroisocoumarin, 5-aminoisoquinolin-1(2H)-one, etc.).

Chemical Properties

White crystalline powder

Uses

Methyl 2-methyl-3-nitrobenzoate may be used in the synthesis of methyl indole-4-carboxylate, 5-aminoisoquinolin-1(2H)-one, 5-nitroisocoumarin and [2-(4-fluorophenyl)-1H-indol-4-yl]-1-pyrrolidinylmethanone. It may also be used in the preparation of substituted nitrostyrene benzoic acids, via reaction with aromatic aldehydes in the presence of DBU in DMSO; and 4-(hydroxymethyl)-1-tosylindole, via Batcho-Leimgruber modification of the Reissert indole synthesis.

Uses

Methyl 2-methyl-3-nitrobenzoate may be used in the synthesis of:

• methyl indole-4-carboxylate
• 5-aminoisoquinolin-1(2H)-one
• 5-nitroisocoumarin
• substituted nitrostyrene benzoic acids, via reaction with aromatic aldehydes in the presence of DBU in DMSO
• 4-(hydroxymethyl)-1-tosylindole, via Batcho-Leimgruber modification of the Reissert indole synthesis
• [2-(4-fluorophenyl)-1H-indol-4-yl]-1-pyrrolidinylmethanone

Solubility in organics

Soluble in methanol.

Methyl 2-methyl-3-nitrobenzoate(59382-59-1)Related Product Information

• Methyl 2-bromobenzoate
• Methyl acrylate
• Methyl anthranilate
• Kresoxim-methyl
• Methylparaben
• Bensulfuron methyl
• METHYL THIOPHENE-2-CARBOXYLATE
• 2-Methyl-3-nitro-benzeneacetic acid
• Trimethoxymethane
• Thiophanate-methyl
• 2-Methyl-3-nitrophenol
• Methyl acetate
• Methyl formate
• Methyl benzoate
• Methyl 2-bromomethyl-3-nitrobenzoate
• METHYL 3-METHYL-4-NITROBENZOATE
• Methyl
• Methyl 2-bromo-3-methylbenzoate