4-Nitro-1-naphthol Chemical Properties

Melting point:

165-168°C

Boiling point:

398.8±25.0 °C(Predicted)

Density 

1.413±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

pka

6.22±0.40(Predicted)

color 

Light yellow to Brown

BRN 

1959672

InChI

InChI=1S/C10H7NO3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6,12H

InChIKey

AUIRNGLMBHIITH-UHFFFAOYSA-N

SMILES

C1(O)=C2C(C=CC=C2)=C([N+]([O-])=O)C=C1

CAS DataBase Reference

605-62-9(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38-41

Safety Statements 

26-36/37/39

RIDADR 

2811

HazardClass 

IRRITANT

HS Code 

29042090

MSDS

• Language:English Provider:ALFA

4-Nitro-1-naphthol Usage And Synthesis

Uses

KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1].

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 906, 1987 DOI: 10.1021/jm00388a027

References

[1] Wapenaar H, et al. The relevance of Ki?calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486. DOI:10.1016/j.ejmech.2017.05.015

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