Rilmenidine phosphate Chemical Properties

storage temp. 

2-8°C

solubility 

Freely soluble in water, slightly soluble in alcohol, practically insoluble in methylene chloride.

form 

Solid

color 

White to off-white

Major Application

pharmaceutical (small molecule)

InChI

1S/C10H16N2O.H3O4P/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10;1-5(2,3)4/h7-9H,1-6H2,(H,11,12);(H3,1,2,3,4)

InChIKey

ZJCOWRFWZOAVFY-UHFFFAOYSA-N

SMILES

[P](=O)([O-])(O)O.[N+H2](C(C3CC3)C2CC2)C1=NCCO1

Safety Information

WGK Germany 

WGK 3

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

Rilmenidine phosphate Usage And Synthesis

Chemical Properties

White or almost white powder.

Uses

Rilmenidine Phosphate is an Imidazoline I1-receptor agonist used in the treatment of hypertension.

Uses

Antihypertensive

Synthesis

In a 1L reaction flask equipped with mechanical stirring, thermometer and reflux condenser, 53.0g (0.46mol) of 2-ethoxyoxazoline, 56.0g (0.50mol) of bicyclopropylmethylamine and 200mL of toluene were added sequentially, stirred thoroughly, then the temperature was raised to reflux and the reaction was kept at reflux for 8h. At the end of the reaction, the temperature was lowered to 25??, to which 5% sodium bicarbonate solution was added. 200 mL was washed, stratification, the organic phase was then washed with 200 mL saturated saline and 200 mL water in turn, anhydrous sodium sulfate drying, filtration, concentration to 76.2 g of the crude product, the crude product was then recrystallized with cyclohexane to obtain 75.0 g of white solid, content of 99.7%, m.p. 105.5~107 ??, yield 90.5%. Rilmenidine phosphate was prepared by salting rilmenidine with phosphoric acid.

Rilmenidine phosphate(85409-38-7)Related Product Information

• Alkaline Phosphatase
• Sodium Phosphate Monobasic Monohydrate
• Ammonium phosphate dibasic
• Trisodium phosphate
• FERRIC PHOSPHATE
• Cefazolin sodium salt
• Pentasodium triphosphate hexhydrate
• Zinc phosphate
• DICALCIUM PHOSPHATE DIHYDRATE
• Cefazolin
• Sodium polyphosphate
• Lithium diisopropylamide
• 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
• Sodium phosphate tribasic dodecahydrate
• Rilmenidine
• Dihydromyrcenol
• Ammonium dihydrogen phosphate
• Calcium phosphate