Daltroban Chemical Properties

Melting point:

132.5-137.4 °C(lit.)

Boiling point:

555.3±60.0 °C(Predicted)

Density 

1.378±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 22 mg/mL, soluble

pka

4.33±0.10(Predicted)

form 

A solid

color 

white

InChI

InChI=1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)

InChIKey

IULOBWFWYDMECP-UHFFFAOYSA-N

SMILES

C1(CC(O)=O)=CC=C(CCNS(C2=CC=C(Cl)C=C2)(=O)=O)C=C1

CAS DataBase Reference

79094-20-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

Daltroban Usage And Synthesis

Description

Daltroban (BM 13505, SKF 96148), a specific thromboxane A2 receptor antagonist, was studied as an antithrombotic agent. Daltroban increases intracellular calcium in vascular smooth muscle cells. Daltroban shows a protective effect in reperfusion injury. The drug was licensed to Smith Kline Beecham and underwent phase III clinical trials in the UK and Germany as an antithrombotic agent but did not enter clinical trials in the USA. Besides, вaltroban was investigated in patients with an ischemic heart disorder. However, the development of daltroban has been discontinued.

Uses

Immunosuppressant.

Uses

Daltroban can be used as a2 receptor to target adipose-derived stem cell for treating ischemic diseases.

Uses

Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist that increases intracellular calcium ions in vascular smooth muscle cells and protects against reperfusion injury after myocardial ischaemia but not in coronary artery endothelial cells. Daltroban may also be useful in the treatment of patients with COPD-related pulmonary hypertension.

target

TXA₂

Daltroban(79094-20-5)Related Product Information

• Methyl chloroacetate
• Pralmorelin
• Ethyl 2-(Chlorosulfonyl)acetate
• Triphenylmethyl Chloride
• Ethyl acetate
• Triphenyltin acetate
• Phenylhydrazine
• DIETHYLALUMINUM CHLORIDE
• Fluroxypyr
• 2-Ethylbutyric acid
• PHENYL VALERATE
• Ethyl chloroacetate
• Chloroacetic acid
• Acetic anhydride
• [4-(2-AMINO-ETHYL)-PHENYL]-ACETIC ACID
• Daltroban