4-Chlorobenzenesulfonyl chloride Chemical Properties

Melting point:

50-52 °C (lit.)

Boiling point:

141 °C/15 mmHg (lit.)

Density 

1.5075 (estimate)

Flash point:

226 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

soluble in Toluene

form 

Liquid

color 

Clear

Water Solubility 

INSOLUBLE

Sensitive 

Moisture Sensitive

BRN 

511583

CAS DataBase Reference

98-60-2(CAS DataBase Reference)

NIST Chemistry Reference

4-Chlorobenzenesulfonyl chloride(98-60-2)

EPA Substance Registry System

Benzenesulfonyl chloride, 4-chloro- (98-60-2)

Safety Information

Hazard Codes 

C

Risk Statements 

34-37

Safety Statements 

26-28-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

2

RTECS 

DB8925000

F 

21

Hazard Note 

Corrosive

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29049020

Hazardous Substances Data

98-60-2(Hazardous Substances Data)

MSDS

• Language:English Provider:4-Chlorobenzenesulfonyl chloride
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4-Chlorobenzenesulfonyl chloride Usage And Synthesis

Chemical Properties

white to light yellow crystals, powder or flakes

Uses

4-Chlorobenzenesulfonyl chloride was used in the synthesis of precursors for the 3,4-pyridyne generation.

Production Methods

4-Chlorobenzenesulfonyl chloride is manufactured by mixing 4-chlorobenzene and chlorosulfuric acid at 35 ℃, heating for two hours at 80 ℃, and discharging the contents of the reactor into ice water; yield 81% of theory, together with a small amount of bis(4-chlorophenyl) sulfone.

Application

Used in the manufacture of chlorobenzenesulfinic acid and sulfimides; three-step reaction to the sulfone in a single reactor is possible without intermediate isolation.

Synthesis Reference(s)

The Journal of Organic Chemistry, 7, p. 15, 1942 DOI: 10.1021/jo01195a003

Purification Methods

Crystallise it from ether in powdered Dry-Ice, after the solution has been washed with 10% NaOH until colourless and dried (Na2SO4). Distil it in vacuo and store it in the absence of H2O. [Beilstein 11 IV 114.]

4-Chlorobenzenesulfonyl chloride(98-60-2)Related Product Information

• 4-Chlorotoluene
• Ammonium chloride
• Sulfuryl chloride
• Calcium chloride
• Polyvinyl chloride
• Chlorobenzene
• Benzyl chloride
• 4-Chlorobenzenesulfonamide
• 4-Chlorophenol
• Mepiquat chloride
• Sodium chloride
• 4-Chlorobenzyl chloride
• N-Acetylsulfanilyl chloride
• Choline chloride
• 4-Chloroaniline
• Benzenesulfonyl chloride
• 4-Nitrobenzenesulfonyl chloride
• alpha-Toluenesulfonyl chloride