TYRAMINE HYDROCHLORIDE Chemical Properties

Melting point:

271-274 °C(lit.)

Boiling point:

269 °C

Density 

1.198±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: 50 mg/mL, clear, colorless

pka

3.50±0.10(Predicted)

form 

White to off-white lyophilized solid

color 

White to Almost white

BRN 

2315783

Sequence

N-Formyl-Met-Leu-Phe-OH

CAS DataBase Reference

59880-97-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-22

WGK Germany 

3

RTECS 

SJ6050000

F 

3-10

HS Code 

2930.90.9250

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

TYRAMINE HYDROCHLORIDE Usage And Synthesis

Uses

Induces leucocyte chemotaxis, and activates macrophages

Uses

N-Formyl-Met-Leu-Phe has been used for:

• creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils
• use in neutrophil chemotaix assay and
• determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.

Definition

ChEBI: A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.

General Description

N-Formyl-Met-Leu-Phe is a chemotactin peptide, which functions on polymorphonuclear leukocytes (PMN), neutrophils etc.

Biochem/physiol Actions

Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.

storage

Store at -20°C

TYRAMINE HYDROCHLORIDE(59880-97-6)Related Product Information

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• TYRAMINE HYDROCHLORIDE
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• BENZYLUREIDO-MET-LEU-PHE-OH
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• N-FORMYL-MET-LEU-P-IODO-PHE
• FORMYL-L-METHIONYL-L-LEUCYL L-PHENYLALANINE, N-[PHENYLALANINE-RING-3,4,5-3H(N)]-