1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE Chemical Properties

Melting point:

72.0 to 76.0 °C

Boiling point:

237.7±35.0 °C(Predicted)

Density 

1.642±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

color 

White to Light yellow

Safety Information

Hazard Codes 

Xn

HS Code 

2909309090

1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE Usage And Synthesis

Synthesis

1. 5-bromo-2-chloro-4-fluorophenol (1.0 g, 4.4 mmol) was dissolved in N,N-dimethylformamide (DMF, 5 mL) in a dry reaction flask. 2. iodomethane (0.55 mL, 8.8 mmol) and potassium carbonate (1.2 g, 8.9 mmol) were added sequentially. 3. The reaction mixture was stirred at room temperature for 20 hours and the progress of the reaction was monitored by thin layer chromatography (TLC). 4. Upon completion of the reaction, the reaction was quenched by adding water (20 mL) to the reaction mixture. 5. The reaction mixture was extracted with ether (20 mL x 3) and the organic phases were combined. 6. The organic phase was washed with saturated saline (20 mL) and dried over anhydrous magnesium sulfate. 7. The desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure to obtain the crude product. 8. The crude product was further purified (if required) to give 5-bromo-2-chloro-4-fluoroanisole (0.951 g, 90% yield) as a white solid. 9. 9. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ3.88 (s, 3H), 7.07 (d, J=5.8 Hz, 1H), 7.19 (d, J=8.0 Hz, 1H) and 19F-NMR (376 MHz, CDCl3): δ-116.1 (s, 1F).

References

[1] Patent: US2016/24110, 2016, A1. Location in patent: Paragraph 0577; 0585
[2] Patent: JP2016/56157, 2016, A. Location in patent: Paragraph 0163
[3] Patent: JP2016/60742, 2016, A. Location in patent: Paragraph 0242; 0244

1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE(146447-18-9)Related Product Information

• 2-Chloro-4-fluoroanisole
• 1-Bromo-4-chloro-2-fluorobenzene
• 5-BROMO-2-CHLORO-4-FLUORO-PHENOL
• 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
• 5-Bromo-2-chlorophenol
• 5-BROMO-2-CHLOROANISOLE
• 3-Bromo-4-fluorophenol