FMOC-LYS(BOC)(ME)-OH Chemical Properties

Melting point:

85-87℃

Boiling point:

665.4±55.0 °C(Predicted)

Density 

1.200

storage temp. 

-20°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

3.88±0.21(Predicted)

color 

White to off-white

InChIKey

JHMSFOFHTAYQLS-QHCPKHFHSA-N

Safety Information

Hazard Codes 

Xi

WGK Germany 

WGK 2 water endangering

HS Code 

2924 29 70

FMOC-LYS(BOC)(ME)-OH Usage And Synthesis

Description

Fmoc-lys (BOC) (ME)-OH is a kind of protected form of lysine. Lysine is double-protected by butyloxycarbonyl (BOC) and 9H-fluoren-9-ylmethoxycarbon (FMOC). It is a derivative for the introduction of monomethyl-lysine during Fmoc SPPS. Coupling can be carried out using any standard activation method. The Boc protecting group can be removed through the TFA-mediated cleavage reaction. As a kind of protected amino acid, it is an important intermediate in various fields such as peptide synthesis, asymmetric synthesis, medicinal chemistry as well as polymer chemistry.

Uses

1. Heterochromatin protein 1 (HP1) depends on trimethylation of H3 Lys 9; aggregation of chromatines depends on Lys methylation
2. Fmoc-Lys(Boc, Me)-OH is useful for preparing monomethylated histone fragments utilized in studying the regulatory roles of methylated histones. Fmoc-Lys(Boc,Me)-OH can be coupled using standard activating procedures. The Boc group on the side epsilon nitrogen atom is removed with TFA, usually at the same time as the peptide is cleaved from the resin.
3. Fmoc-Lys(Boc, Me)-OH is a novel derivative for the introduction of monomethyl-lysine during Fmoc SPPS. Coupling can be carried out using any standard activation method. Removal of the Boc protecting group occurs during the course of the TFA-mediated cleavage reaction.

General Description

Fmoc protected N-methylated lysine

References

http://www.chempep.com/ChemPep_Products2_Fmoc-Amino-Acid_Fmoc-Lys_Boc_Me_-OH.htm
https://en.wikipedia.org/wiki/Peptide_synthesis
Tung, C. L., et al. "A fluorogenic probe for recognizing 5-hydroxylysine inspired by serine/threonine ligation. " Chemical Communications 50.40(2014):5298-300.

FMOC-LYS(BOC)(ME)-OH(951695-85-5)Related Product Information

• (s)-3-(fmoc-amino)-n-trityl-adipic acid 6-amide
• FMoc-Aea-OH
• N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE
• FMOC-LYS(DNP)-OH
• Fmoc-Lys(Trt)-OH
• FMOC-D-LYS(IVDDE)-OH
• FMOC-LYS(ME)2-OH HCL
• FMOC-LYS(ME3)-OH HCL
• Fmoc-L-beta-Homoarginine(Pmc)
• Fmoc-N'-Acetyl-L-lysine
• Fmoc-Lys(Pal-Glu-OtBu)-OH
• Fmoc-Lys(N3)-OH
• FMOC-LYS(FMOC)-OH
• Fmoc-L-Lys(Dde)-OH
• Fmoc-Lys(Ddiv)-OH
• FMOC-LYS(BOC)(ISOPROPYL)-OH
• FMOC-LYS(BOC-ABZ)-OH
• FMOC-LYS(BOC)-LEU-OH