1-(5-Chloro-2-hydroxyphenyl)ethanone Chemical Properties

Melting point:

54-56 °C(lit.)

Boiling point:

126-128 °C28 mm Hg(lit.)

Density 

1.2315 (rough estimate)

refractive index 

1.5590 (estimate)

Flash point:

107-109°C/12mm

storage temp. 

Sealed in dry,Room Temperature

form 

Solid

pka

9.72±0.18(Predicted)

BRN 

1365589

InChIKey

XTGCUDZCCIRWHL-UHFFFAOYSA-N

CAS DataBase Reference

1450-74-4(CAS DataBase Reference)

NIST Chemistry Reference

Ethanone, 1-(5-chloro-2-hydroxyphenyl)-(1450-74-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29147000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-(5-Chloro-2-hydroxyphenyl)ethanone Usage And Synthesis

Chemical Properties

slightly yellow crystalline powder or chunks

Uses

5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) may be used in the synthesis of:

• 6-chloro-2-methyl-4H-chrome-4-one
• 1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
• 1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
• 2-styrenyl allyl ether

Preparation

Preparation by Fries rearrangement of 4-chlorophenyl acetate with aluminium chloride without solvent between 110° and 200°(90–100% yield).

General Description

5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) on condensation with salicylhydrazide yields Schiff base, which is reported to form copper(II) complexes. Dipole moment of 5-chloro-2- hydroxyacetophenone has been evaluated in benzene solution.

1-(5-Chloro-2-hydroxyphenyl)ethanone(1450-74-4)Related Product Information

• 6-CHLOROCHROMAN-4-ONE
• 6,8-DICHLORO-3-FORMYLCHROMONE
• 5-Chloro-2-hydroxybenzophenone
• (+)-Griseofulvin
• 1-(5-Chloro-2-hydroxyphenyl)ethanone
• 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE
• 2-AMINO-6-CHLORO-3-FORMYLCHROMONE
• MECLOCYCLINE SULFOSALICYLATE SALT
• Demeclocycline hydrochloride
• 5-CHLORO-BENZOFURAN-3-ONE
• Chlortetracycline hydrochloride
• 5-CHLORO-2-HYDROXY-4-METHYLBENZOPHENONE
• 1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone,1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone, 5-Chloro-3-bromo-2-hydroxyacetophenone
• 2-Chloro-3',4'-dihydroxyacetophenone
• 2-BROMO-1-(5-CHLORO-2-HYDROXYPHENYL)ETHANONE
• 1-(2-Chloro-6-hydroxyphenyl)ethanone
• 2'-Chloro-4'-hydroxyacetophenone
• 1-(4-CHLORO-2-HYDROXYPHENYL)ETHANONE