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ACETARSONE

Basic information Safety Supplier Related

ACETARSONE Basic information

Product Name:
ACETARSONE
Synonyms:
  • paaroxyl
  • stovarsole
  • acetphenarine
  • amasan
  • ethrlich594
  • Acetarsone;Devegan;Qrarsan;Qsarsal;Osarsol;Osvarsan;Paroxyl;Sanogyl;Spirocid;S.V.C;Monargan;Kharophen
  • Qrarsan
  • Qsarsal
CAS:
97-44-9
MF:
C8H10AsNO5
MW:
275.09
EINECS:
202-582-3
Product Categories:
  • STOVARSOL
Mol File:
97-44-9.mol
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ACETARSONE Chemical Properties

Melting point:
220.5°C
Boiling point:
72.17°C
Density 
1.0325 g/cm3(Temp: 15 °C)
form 
solid
pka
pKa 3.73 (H2O t=26) (Uncertain);7.9 (Uncertain); 9.3(H2O) (Uncertain)
color 
Crystalline material
Merck 
13,53
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Safety Information

Hazard Codes 
T,N
Risk Statements 
23/25-50/53
Safety Statements 
20/21-28-45-60-61
RIDADR 
UN 3465 6.1/PG 2
WGK Germany 
3
RTECS 
CF8400000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
MLD in rabbits, cats (mg/kg): 125-150, 150-175 orally (Anderson, Leake)

MSDS

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ACETARSONE Usage And Synthesis

Originator

Acetarsol ,Cyklo Pharma Chem Pvt. Ltd.

Uses

antiprotozoal; diethylamine salt as antiphilitic

Manufacturing Process

1 part of 4-chloroaniline is dissolved with 2 parts of concentrated hydrochloric acid (specific gravity 1.16) and 10 parts of water, and diazotised in the usual manner. 3 parts of sodium arsenite are introduced into the diazo solution thus obtained, the sodium arsenite being dissolved in 5 parts of water and 1 part of 96% ethanol. The solution is heated slowly to 70°C. When evolution of nitrogene ceased, it is filtered from separated oil and the addition of hydrochloric acid precipitates the 4-chlorophenylarsonic acid, which crystallizes out in the form of white needles.
By action HNO3/H2SO4 on 4-chlorophenylarsonic acid is obtained 4-chloro-3- nitrophenylarsonic acid which is converted at 100°C with 33% aqueous solution of sodium hydroxide to 4-hydroxy-3-nitrophenylarsonic acid. After reduction of NO2 group of 4-hydroxy-3-nitrophenylarsonic acid by the action of Na2S2O3 or Fe/NaOH is obtained 3-amino-4-hydroxyphenylarsonic acid. From 3-amino-4-hydroxyphenylarsonic acid and acetic anhydride is prepared N-acetyl-4-hydroxy-m-arsanilic acid.

brand name

190 f;Acetarsolum;Amarson;Arsabott;Auryphan;Chrlich 594;Collarsin;Edoiacolo;Ehrlich 594;F 190;Fluryl;Fourneau 190;Kharophene;Neo-vagex;Pallacid;Trichovan;Vagipurin;Vagisep;Vagival.

Therapeutic Function

Antiprotozoal, Tonic

World Health Organization (WHO)

Acetarsol, which has antiprotozoal and antitrichomonal activity, has largely been discarded for systemic use because of its potential to cause systemic poisoning. However, topical preparations for vaginal trichomoniasis are still available and it is included in low concentrations (equal to or less than 0.45%) in some medicated toothpastes.

Safety Profile

Poison by ingestion and intravenous routes. Human systemic effects by ingestion: respiratory system, endocrine system, dermatitis, and fever. Human systemic effects by intravagmal route: hallucinations, dlstorted perceptions, convulsions, nausea or vomiting, decreased urine volume, and fever. Mutation data reported. See also ARSENIC COMPOUNDS. When heated to decomposition it emits very toxic fumes of NOx, and As

Purification Methods

It crystallises from water in colourless prisms. It decomposes slowly on prolonged boiling in H2O or dilute alkalis. The N-propionyl derivative recrystallises from H2O with m 228-229o(dec). [Raiziss & Fisher J Am Chem Soc 48 1323 1926, Hewitt & King J Chem Soc 823 1926, Beilstein 16 I 491, 16 II 521, 16 III 1129.]

ACETARSONE Preparation Products And Raw materials

Raw materials

ACETARSONESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Email
3bsc@sina.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Email
info@tsbiochem.com
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
Email
sales@heowns.com
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566-
Email
sales@mreda.com.cn