2-HYDROXYFORMANILIDE Chemical Properties

Melting point:

182-183 °C

Boiling point:

338.4±25.0 °C(Predicted)

Density 

1.310±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: 1 mg/mL,DMSO: 1 mg/mL,PBS (pH 7.2): 0.16 mg/mL

form 

A solid

pka

9.19±0.35(Predicted)

2-HYDROXYFORMANILIDE Usage And Synthesis

Biological Activity

N-formyl-2-Aminophenol is a bacterial secondary metabolite that has been found in P. chrysogenum and has antioxidant activity.1,2 It scavenges DPPH radicals in a cell-free assay with an IC50 value of 3.23 μg/ml.2 N-formyl-2-Aminophenol has also been used in the synthesis of compounds with antibacterial and antifungal activities.3

References

1.Frisvad, J.C., Smedsgaard, J., Larsen, T.O., et al.Mycotoxins, drugs and other extrolites produced by species in Penicillium subgenus PenicilliumStud. Mycol.49201-241(2004) 2.Deepali, A., Akansha, A., Anamika, B., et al.Hydroxylamine hydrochloride as an effective catalyst for form amide derivative synthesis and their DPPH scavenging activityRes. J. Chem. Sci.4(10)54-57(2014) 3.Gupta, S., Verma, P., and Singh, V.Synthesis and antimicrobial study of 2-amino-imidazole derivativesIndian J. Chem. 57B679-686(2018)

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