Emodin-3-methyl ether
Emodin-3-methyl ether Basic information
- Product Name:
- Emodin-3-methyl ether
- Synonyms:
-
- 3-methoxy-6-methyl-
- 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone
- EMODIN-3-METHYLETHER(RG)(CALL)
- 1,8-Dihydroxy-3-Methoxy-6-Methyl-
- Rheochrysidin (Physcione)
- MethyleModin
- Physcic acid
- Przewalskinone B
- CAS:
- 521-61-9
- MF:
- C16H12O5
- MW:
- 284.26
- EINECS:
- 208-315-7
- Product Categories:
-
- Agro-Products
- Aromatics
- Inhibitors
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- The group of Polydatin
- Anthraquinones, Hydroquinones and Quinones
- Mol File:
- 521-61-9.mol
Emodin-3-methyl ether Chemical Properties
- Melting point:
- 196-206°C
- Boiling point:
- 560.5±50.0 °C(Predicted)
- Density
- 1.448±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
- form
- Solid
- pka
- 6.23±0.20(Predicted)
- color
- Yellow to Dark Yellow to Dark Orange
- BRN
- 6770499
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
- InChIKey
- FFWOKTFYGVYKIR-UHFFFAOYSA-N
- SMILES
- C1(O)=C2C(C(=O)C3=C(C2=O)C(O)=CC(C)=C3)=CC(OC)=C1
- LogP
- 5.078 (est)
- CAS DataBase Reference
- 521-61-9(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
Emodin-3-methyl ether Usage And Synthesis
Chemical Properties
Yellow Solid
Uses
antibacterial, cathartic
Uses
A natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.
Definition
ChEBI: A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6.
Biological Activity
Anthraquinone-derivative found in medicinal herbs.
in vivo
Physcion (20 or 40 mg/kg, p.o., once daily for 7 days) exerts neuroprotective effects by inhibiting the TLR4/NF-κB signaling pathway in an ischemia-reperfusion-induced SD rat model[3]. Physcion (4 or 9 mg/kg, p.o., once daily for 6 days) effectively alleviates infection symptoms caused by Chlamydia psittaci 6 BCE in SPF chickens[4].
| Animal Model: | Ischemia-reperfusion (I/R)-induced focal cerebral ischemia model in SD rats[3] |
| Dosage: | 20 or 40 mg/kg |
| Administration: | Oral gavage (p.o.), once daily for 7 days |
| Result: | Significantly reduced the brain water content and the NSS (Neurological Severity Score) in I/R rats, compared to I/R group. Obviously decreased areas of infarction compared to I/R group. |
| Animal Model: | SPF chickens (21 days old) infected intra-laryngeally with Chlamydia psittaci 6 BCE[4] |
| Dosage: | 4 or 9 mg/kg |
| Administration: | Oral gavage (p.o.), once daily for 6 days |
| Result: | Dose-dependently alleviated respiratory distress, air sac and lung lesions, and bacterial load in the spleen in infected chickens. |
IC 50
TLR4
Emodin-3-methyl etherSupplier
- Tel
- 13186333400
- m13108465082@163.com
- Tel
- 13186333400
- cuichengbio@163.com
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 4006356688 18621169109
- market03@meryer.com
- Tel
- 400-0066400 13621662912
- sales@jonln.com