6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID Chemical Properties

Boiling point:

446.7±45.0 °C(Predicted)

Density 

1.804±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

2.54±0.20(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

HazardClass 

IRRITANT

HS Code 

2933491090

6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID Usage And Synthesis

Synthesis

6-Bromo-2-hydroxy-4-carboxylic acid quinoline was synthesized using the method described in Scheme 6. The procedure was as follows: 5-bromoindoline-2,3-dione (0.250 g) was dissolved in tetrahydrofuran (THF, 3 ml) in a round-bottomed flask, followed by the addition of malonic acid (2 equiv). The unit was connected to a reflux condenser and heated to reflux by conventional heating and the reaction was continued overnight. After 12 hours of reaction, a solid precipitate was observed to be generated. Subsequently, the suspension was concentrated under reduced pressure to remove the solvent, and the suspension was refluxed for 4 hours after addition of an appropriate amount of water. Finally, the solid product was collected by filtration to afford 6-bromo-2-hydroxyquinoline-4-carboxylic acid (0.150 g) in solid form.

References

[1] Patent: US2014/221387, 2014, A1. Location in patent: Paragraph 0383; 0384; 0385

6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID(5463-29-6)Related Product Information

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