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(SAR9,MET(O2)11)-SUBSTANCE P

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(SAR9,MET(O2)11)-SUBSTANCE P Basic information

Product Name:
(SAR9,MET(O2)11)-SUBSTANCE P
Synonyms:
  • (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfonyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide
  • [Sar9,Met(O2)11]-Substance P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2?, >98%
  • [SAR9,MET(O2)11]-SUBSTANCE P?, >98%
  • H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET(O2)-NH2
  • ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET(O2)-NH2
  • (SAR9,MET(O2)11)-SUBSTANCE P
  • RPKPQQFFSARLM(O2)
  • [SAR9 ,MET(O2 )11 ]-SUBSTANCE P HIGHLY SPECIFIC NEUROKININ NK1 RECEPTOR 97+%
CAS:
110880-55-2
MF:
C64H100N18O15S
MW:
1393.66
Product Categories:
  • Tachykinin receptor
Mol File:
110880-55-2.mol
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(SAR9,MET(O2)11)-SUBSTANCE P Chemical Properties

Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O : 50 mg/mL (35.88 mM; Need ultrasonic)
form 
Lyophilized solid.
pka
13.31±0.20(Predicted)
color 
White to off-white
Water Solubility 
Soluble to 1 mg/ml in water
Sequence
H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-NH2
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Safety Information

WGK Germany 
3

MSDS

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(SAR9,MET(O2)11)-SUBSTANCE P Usage And Synthesis

Uses

[Sar9,Met(O2)11]-Substance P is a potent and selective NK1 tachykinin receptor agonist (1). The NK1 tachykinin receptor is a member of the G-protein coupled receptor family and can be found in neurons, brainstem, and vascular endothelial cells (2,3). NK1 tachykinin receptor is a therapeutic target for pancreatic cancer (4).

Biochem/physiol Actions

Highly selective NK-1 receptor agonist.

storage

Store at -20°C

(SAR9,MET(O2)11)-SUBSTANCE PSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
GL Biochem (Shanghai) Ltd
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21-61263452 13641803416
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ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
Chemsky（shanghai）International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
MedChemexpress LLC
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021-58955995
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sales@medchemexpress.cn
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