Basic information Safety Supplier Related

H-CYS-4-ABZ-MET-OH

Basic information Safety Supplier Related

H-CYS-4-ABZ-MET-OH Basic information

Product Name:
H-CYS-4-ABZ-MET-OH
Synonyms:
  • H-CYS-4-ABZ-MET-OH
  • FTASE INHIBITOR II
  • CYSTEINE-(4-AMINOBENOZYL)METHIONINE
  • L-Methionine,N-[4-[[(2R)-2-aMino-3-Mercapto-1-oxopropyl]aMino]benzoyl]-
  • (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]benzoyl]amino]-4-methylsulfanylbutanoic acid
  • FTI II
  • N-[4-[[(2R)-2-Amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine
  • FTase Inhibitor II(TFA salt)
CAS:
156707-43-6
MF:
C15H21N3O4S2
MW:
371.47
Mol File:
156707-43-6.mol
More
Less

H-CYS-4-ABZ-MET-OH Chemical Properties

Boiling point:
700.6±60.0 °C(Predicted)
Density 
1.363±0.06 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
≤25mg/ml in
pka
3.46±0.10(Predicted)
form 
crystalline solid
More
Less

H-CYS-4-ABZ-MET-OH Usage And Synthesis

Uses

FTase Inhibitor II acts as a cell permeable analog of farnesyl pyrophosphate (FPP) that potently inhibits FTase. Possible cancer therapeutic agent

Biological Activity

ftase inhibitor ii is a potent farnesyl transferase inhibitor.protein prenylation is reported as a key mechanism by which functional association of proteins to membranes is mediated. ras proteins that are regulators of cell proliferation and differentiation are among the proteins undergoing farnesylation.

in vitro

previous study found that cells were treated with ftase inhibitor ii and two ggtase inhibitors (ggti-286 and ggti-2147) and the results showed that there was no change in cell growth in the presence of these inhibitors, even when 100 μm of the drugs were added to the culture. in addition, when cells were treated with a combination of ggti-2147 and ftase inhibitor ii, ranging from 0.1 nm to 100 μm, cell growth was not affected. additionally, in the presence of both 50 μm ftase inhibitor ii and 50 μm ggti-2147, the ftase and ggtase i enzyme activities were abolished [1].

References

[1] v. manne, c. s. ricca, j. g. brown, et al. ras farnesylation as a target for novel antitumor agents: potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase. drug development research 34, 121-137 (1995).

H-CYS-4-ABZ-MET-OHSupplier

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Email
sales@njleonbiotech.com