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Endothelin-1 (human, porcine)

Basic information Description Safety Supplier Related

Endothelin-1 (human, porcine) Basic information

Product Name:
Endothelin-1 (human, porcine)
Synonyms:
  • ET-1
  • ET-1, HUMAN
  • ET-1, HUMAN AND PORCINE
  • ET-1 (HUMAN, BOVINE, DOG, MOUSE, PORCINE, RAT)
  • ET-1 (HUMAN, MOUSE, RAT, PIG, BOVINE, DOG)
  • ET-1, HUMAN, PORCINE
  • ET-1 (HUMAN, PORCINE, DOG, RAT)
  • ENDOTHELIN-I, HUMAN, PORCINE
CAS:
117399-94-7
MF:
C109H159N25O32S5
MW:
2491.9
Product Categories:
  • amino
  • Peptide
  • Endothelin receptor
Mol File:
117399-94-7.mol
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Endothelin-1 (human, porcine) Chemical Properties

Boiling point:
2467.3±65.0 °C(Predicted)
Density 
1.273±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
1% acetic acid: >1 mg/mL
form 
powder
color 
white
Water Solubility 
Soluble in water.
Merck 
13,3610
InChIKey
ZUBDGKVDJUIMQQ-UHFFFAOYSA-N
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Safety Information

WGK Germany 
3
RTECS 
KE9446500
3-10
HS Code 
2937190000

MSDS

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Endothelin-1 (human, porcine) Usage And Synthesis

Description

Endothelin-1 (human, porcine) is an active peptide with strong vasoconstriction effect isolated from the supernatant of cultured porcine aortic endothelial cells. Endothelin 1 has been shown to be present in many mammals, including humans. Although vascular endothelial cells are the main source of endothelin 1, cardiomyocytes, vascular smooth muscle cells, renal tubular epithelial cells and glial cells can all produce endothelin 1, suggesting that endothelin 1 can independently participate in the complex regulatory mechanism of various organs.

Uses

Endothelin-1 (human, porcine) has been used for coating wells in polystyrene ELISA plates. Potent agonist for ETA and ETB endothelia receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.

Application

Endothelin-1 (human, porcine) has been used:
to study its effects on the production of erythropoietin under normoxia and carbon monoxide-induced hypoxia in rat models.
as a protein kinase C (PKC) agonist to study its effects on the phosphorylation of myofilament proteins in rat myocytes.
to induce a hypertrophic-like state to study its effects on contraction pressure in normal and mutated human induced pluripotent stem cells (hiPSC)-derived cardiomyocytes.
in vitro hydrolysis products of macroendothelin-1, a precursor of endothelin-1, and their pharmacodynamic properties in rabbits.
as a receptor for endothelin-1 and its role in G protein-mediated signal transduction Research.

Biological Functions

Endothelins are a family of vasoactive peptides secreted by endothelial cells. The three major endothelin peptides are all composed of 21 amino acids. Endothelins are the most potent vasoconstrictors known. Contraction of vascular smooth muscle in response to endothelin is associated with an increase in intracellular calcium. Increases in endothelin levels have been reported in patients with vasospastic, hypoxic, and ischemic diseases.The two identified isoforms of endothelin receptors have differing affinity for the three endothelin peptides. Selective and nonselective endothelin receptor antagonists are in development for potential use in the treatment of hypertension and other disorders associated with increased vascular resistance.

Biological Activity

Endothelin 1 (human, porcine) is an endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide isolated from porcine endothelial cells. ET-1 is widely present at binding sites in blood vessels, heart, kidneys, adrenal glands, lungs, and brain, and its distribution is similar to endothelial cells.

Biochem/physiol Actions

Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.

storage

-20°C (desiccate)

Endothelin-1 (human, porcine)Supplier

Hangzhou Peptidego Biotech Co.,Ltd. Gold
Tel
0571-87213919
Email
Eric@peptidego.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com