Dipeptide-2 Chemical Properties

Boiling point:

604.8±55.0 °C(Predicted)

Density 

1.268±0.06 g/cm3(Predicted)

storage temp. 

−20°C

pka

3.14±0.10(Predicted)

form 

Solid

color 

White to off-white

Sequence

Val-Trp

InChI

InChI=1S/C16H21N3O3/c1-9(2)14(17)15(20)19-13(16(21)22)7-10-8-18-12-6-4-3-5-11(10)12/h3-6,8-9,13-14,18H,7,17H2,1-2H3,(H,19,20)(H,21,22)/t13-,14-/m0/s1

InChIKey

LZDNBBYBDGBADK-KBPBESRZSA-N

SMILES

C(O)(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](C(C)C)N

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

Dipeptide-2 Usage And Synthesis

Description

Dipeptide-2 is a tiny peptide with only two amino acids (amino acids are the building block of proteins, and peptides are a few amino acids attached together), Valine and Tryptophan. It's part of a 3 actives complex called Eyeliss (with HMC and Palmitoyl Tetrapeptide-7) that's supposed to fight under-eye bags.
The manufacturer claims that this dipeptide in Eyeliss can increase lymphatic circulation and the three actives together represent a "global approach to treating puffy eyes". The clinical study of the manufacturer with 20 people and 3% Eyeliss showed improvement after 56 days for 70% of the participants.

Chemical Properties

H-VAL-TRP-OH is a white or off-white lyophilized powder.

Uses

Dipeptide 2 (N-Valyltryptophan; Val-Trp) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient[1]. Dipeptide 2 is an angiotensin-converting Enzyme (ACE)[2].

Definition

ChEBI: Dipeptide-2 is a synthetic peptide used for skin care.

Mode of action

Dipeptide-2 is a potent angiotensin-converting enzyme (ACE) inhibitor, which reduces vasoconstriction of blood vessels around the eyes by inhibiting ACE activity and promotes blood circulation, thus improving periorbital edema and reducing dark circles.

References

[1] Zhang L, et al. Cosmeceuticals and peptides. Clin Dermatol. 2009;27(5):485-494. DOI:10.1016/j.clindermatol.2009.05.013
[2] Bicak B. Structural, spectroscopic, molecular docking, ADME, molecular dynamics studies of Val-Trp dipeptide. J Biomol Struct Dyn. 2023;41(23):13873-13890. DOI:10.1080/07391102.2023.2183041

Dipeptide-2(24587-37-9)Related Product Information

• ALPHA-METHYL-L-TRYPTOPHAN
• H-VAL-PNA HCL
• L-Valine benzyl ester hydrochloride
• H-VAL-ILE-OH
• H-VAL-ALA-OH
• ALPHA-METHYL-L-VALINE HYDROCHLORIDE
• H-VAL-VAL-OH
• A-METHYL-L-TRYPTOPHAN
• L-VALINE TERT-BUTYL ESTER HYDROCHLORIDE
• L-Valine methyl ester hydrochloride
• L-Valine benzyl ester 4-toluenesulfonate
• ALPHA-METHYL-DL-HISTIDINE DIHYDROCHLORIDE
• H-α-Me-Tyr(tBu)-OH
• H-VAL-TYR-OH
• H-VAL-NH2 HCL
• H-ALPHA-ME-D-VAL-OH
• Endothelin-1 (human, porcine)
• Dipeptide-2