BQ-3020
BQ-3020 Basic information
- Product Name:
- BQ-3020
- Synonyms:
-
- N-AC, ALA11,15-ENDOTHELIN 1, 6-21
- N-ACETYL[ALA11,15]-ENDOTHELIN-1 (6-21)
- N-ACETYL-[ALA11,15]ENDOTHELIN-I (6-21)
- AC-(ALA11,15)-ENDOTHELIN-1 (6-21)
- BQ-3020
- ENDOTHELIN-1(6-21), N-ACETYL-[ALA11,15]-
- Acetyl-(Ala11·15)-Endothelin-1 (6-21) Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
- ACETYL-(ALA11,15)-ENDOTHELIN-1 (6-21)
- CAS:
- 143113-45-5
- MF:
- C96H140N20O25S
- MW:
- 2006.34
- Product Categories:
-
- Endothelin receptor
- Mol File:
- 143113-45-5.mol
BQ-3020 Chemical Properties
- Boiling point:
- 2125.8±65.0 °C(Predicted)
- Density
- 1.287±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M)
- pka
- 3.39±0.10(Predicted)
- form
- powder
- color
- white
- Sensitive
- Light Sensitive
- Sequence
- Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
MSDS
- Language:English Provider:SigmaAldrich
BQ-3020 Usage And Synthesis
Uses
BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.
Biological Activity
BQ-3020, a linear endothelin analog, is a selective ETB endothelin receptor agonist.
in vivo
BQ-3020 (3 mg/kg for i.h., single dose) attenuates cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection in cancer pain mouse model[3].
| Animal Model: | Cancer pain mouse model [3] |
| Dosage: | 3 mg/kg |
| Administration: | Injected subcutaneously at the site of the greatest tumor development |
| Result: | Attenuated cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection |
IC 50
ETB: 0.2 nM (IC50)
storage
-20°C
References
[1] Arteaga JL,et.al. Endothelin ET(B) receptors are involved in the relaxation to the pig urinary bladder neck. Neurourol Urodyn. 2012 Jun;31(5):688-94. DOI:10.1002/nau.22203
[2] Ihara M, et.al. A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors. Life Sci. 1992;51(6):PL47-52. DOI:10.1016/0024-3205(92)90418-o
[3] Quang PN, et.al. Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain. 2010 May;149(2):254-262. DOI:10.1016/j.pain.2010.02.009
BQ-3020Supplier
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 0551-65326643 18156095617
- info@cellmano.com