MURISTERONE A Chemical Properties

Boiling point:

707.2±60.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Soluble in DMSO

form 

solid

pka

11.78±0.70(Predicted)

color 

white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

MURISTERONE A Usage And Synthesis

Description

Muristerone A is a natural analog of 20-hydroxyecdysone . It is an agonist of the ecdysteroid receptor (K_d = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells. However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies.

Uses

Muristerone A, an ecdysteroid, is widely used for the induction of ecdysteroid-dependent transcription in mammalian cells.

Biological Activity

Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.

storage

+4°C

References

[1] A C ZELHOF. Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1995, 92 23: 10477-10481. DOI: 10.1073/pnas.92.23.10477
[2] T M LANDON. Characterization and partial purification of the Drosophila Kc cell ecdysteroid receptor.[J]. The Journal of Biological Chemistry, 1988, 263 10: 4693-4697.
[3] MARKUS LEZZI. Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle[J]. The FEBS journal, 2009, 269 13: 3237-3245. DOI: 10.1046/j.1432-1033.2002.03001.x
[4] D NO  R M E  T P Yao. Ecdysone-inducible gene expression in mammalian cells and transgenic mice.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 8: 3346-3351. DOI: 10.1073/pnas.93.8.3346
[5] E SAEZ. Identification of ligands and coligands for the ecdysone-regulated gene switch.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 26: 14512-14517. DOI: 10.1073/pnas.260499497
[6] I OEHME  M Z  S B?sser. Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO[J]. Cell Death and Differentiation, 2005, 13 2: 189-201. DOI: 10.1038/sj.cdd.4401730

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