MURISTERONE A Chemical Properties

Boiling point:

707.2±60.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Soluble in DMSO

form 

solid

pka

11.78±0.70(Predicted)

color 

white

Safety Information

WGK Germany 

3

MSDS

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MURISTERONE A Usage And Synthesis

Description

Muristerone A is a natural analog of 20-hydroxyecdysone . It is an agonist of the ecdysteroid receptor (K_d = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells. However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies.

Uses

Muristerone A, an ecdysteroid, is widely used for the induction of ecdysteroid-dependent transcription in mammalian cells.

Biological Activity

Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.

storage

+4°C

MURISTERONE A(38778-30-2)Related Product Information

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