Mal-PEG2-Val-Cit-amido-PAB-OH Chemical Properties

Boiling point:

948.4±65.0 °C(Predicted)

Density 

1.294±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO, DMF

pka

13.41±0.70(Predicted)

form 

Solid

color 

White to off-white

Mal-PEG2-Val-Cit-amido-PAB-OH Usage And Synthesis

Description

Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The maleimide group is reactive toward thiol groups between pH 6.5 to 7.5. PEG chain increases the water solubility of the compound.

Uses

Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-Val-Cit-PAB-OH also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

IC 50

Cleavable Linker; Protease Cleavable Linker; PEGs

Mal-PEG2-Val-Cit-amido-PAB-OH(2055041-38-6)Related Product Information

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