Mal-PEG2-acid
Mal-PEG2-acid Basic information
- Product Name:
- Mal-PEG2-acid
- Synonyms:
-
- Mal-PEG2-acid
- Maleimide-PEG2-CH2CH2COOH
- Mal-PEG2-CH2CH2COOH
- Mal-NH-PEG2-acid
- 3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic acid
- α-Maleimidyl-ω-propionyloxy poly(ethylene glycol)
- Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-
- 3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid
- CAS:
- 1374666-32-6
- MF:
- C11H15NO6
- MW:
- 257.24
- Product Categories:
-
- peg
- Mol File:
- 1374666-32-6.mol
Mal-PEG2-acid Chemical Properties
- Boiling point:
- 455.7±35.0 °C(Predicted)
- Density
- 1.329±0.06 g/cm3(Predicted)
- pka
- 4.27±0.10(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- CAS DataBase Reference
- 1374666-32-6
Mal-PEG2-acid Usage And Synthesis
Description
Mal-PEG2-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Mal-PEG2-acid is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It can bind to Tubulysin (HY-128914) and its cytotoxic derivatives activity. It can also be used as a PROTAC linker for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Non-cleavable < span> | PEGs
|
Mal-PEG2-acidSupplier
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- 573-573-82623377 18967387295
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- 021-34975603-808 18721111801
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- 021-50460086-9 15921403865
- han_yajun@dctc.daicel.com
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- 03-36680489
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- 320-37350700
- sales@tcieurope.eu
Mal-PEG2-acid(1374666-32-6)Related Product Information
- N-Benzylmaleimide
- Mal-PEG6-Acid
- Maleimido-Tri(Ethylene Glycol)-Propionic Acid
- Mal-PEG2-COOH
- N-[4-(-Carboxycyclohexylmethyl)]maleimide
- Mal-PEG4-Acid
- Mal-PEG2-NHS ester
- Bis-Mal-Lysine-PEG4-TFP ester
- Maleimide-PEG4-NHS Ester
- 3-Maleimidopropionic acid
- Mal-Amido-PEG4-acid
- 2-MALEIMIDOETHYLAMINE HCL
- Mal-PEG12-NHS ester
- Mal-PEG8-acid
- Mal-PEG12-NH-Boc
- alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol)
- Mal-PEG12-ALD
- Maleimide-PEG2-NHS Ester