Basic information Safety Supplier Related

paraflutizide

Basic information Safety Supplier Related

paraflutizide Basic information

Product Name:
paraflutizide
Synonyms:
  • paraflutizide
  • 6-Chloro-3-(p-fluorobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • LD-3612
  • 6-chloro-3-(4-fluorobenzyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 6-chloro-3-[(4-fluorophenyl)methyl]-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[(4-fluorophenyl)methyl]-3,4-dihydro-, 1,1-dioxide
CAS:
1580-83-2
MF:
C14H13ClFN3O4S2
MW:
405.85
EINECS:
216-426-7
Mol File:
1580-83-2.mol
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paraflutizide Chemical Properties

Melting point:
238-240°
Boiling point:
636.2±65.0 °C(Predicted)
Density 
1.571±0.06 g/cm3(Predicted)
pka
8.66±0.40(Predicted)
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Safety Information

Toxicity
LD50 oral in mouse: > 10gm/kg
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paraflutizide Usage And Synthesis

Originator

Paraflutizide, Shanghai Lansheng

Manufacturing Process

A mixture of 5.0 g (0.0357 g/mol) of ρ-fluorophenylethyl alcohol, 2.0 g (0.007 g/mol) of 5-chloro-2,4-disulphamylaniline, 2.0 g (0.0068 g/mol) of potassium bichromate and 15 ml of concentrated hydrochloric acid (0.176 g/mol) and 25 ml of water is heated under reflux for 1 h. The mixture is allowed to cool, and 15 ml of ether are added to separate the excess of ρ-fluorophenylethyl alcohol. The aqueous layer is decanted and frozen for 2 h and the precipitate is separated, washed with water and dried in vacuum over phosphoric anhydride. There are collected 1.35 g (yield 47.5%) of the 1,1-dioxide of 3-ρfluorophenyl-methyl-7-sulphamyl-6-chloro-3,4-dihydrobenzo-1,2,4-thiadiazine, which when recrystallised from 30 ml of 50% alcohol on "Norit" active carbon takes the form of a white crystalline substance, melting point is 239°C.

Therapeutic Function

Diuretic

paraflutizideSupplier

Alfa Chemistry
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1-201-478-8534
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