ethiazide Chemical Properties

Melting point:

269-270°

Boiling point:

563.5±60.0 °C(Predicted)

Density 

1.526±0.06 g/cm3(Predicted)

pka

9.01±0.40(Predicted)

ethiazide Usage And Synthesis

Originator

Ethiazide,Tokyo Tanabe,Japan,1970

Definition

ChEBI: Ethiazide is a benzothiadiazine.

Manufacturing Process

A mixture of 2.9 grams of 5-chloro-2,4-disulfamyl-aniline in 20 ml of anhydrous diethylene glycoldimethylether, 0.44 gram of propionaldehyde and 0.5 ml of a solution of hydrogen chloride in ethyl acetate (109.5 grams hydrogen chloride per 1,000 ml) is heated to 80° to 90°C and maintained at that temperature for 1 hour. The reaction mixture is concentrated under reduced pressure; on addition of water, the product separates and is then recrystallized from ethanol or aqueous ethanol to yield the desired 6-chloro-3- ethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide, MP 269° to 270°C.

Therapeutic Function

Diuretic, Cardiotonic, Smooth muscle relaxant, Respiratory stimulant

ethiazide(1824-58-4)Related Product Information

• Chlorothiazide
• butizide
• Benzyldihydrochlorothiazide
• paraflutizide
• Cyclopenthiazide
• CYCLOTHIAZIDE
• BENZYLHYDROCHLOROTHIAZIDE
• mebutizide
• bemetizide
• ethiazide