piperidine-4-propanol Chemical Properties

Melting point:

65 °C

Boiling point:

235℃

Density 

0.929

Flash point:

90℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

15.16±0.10(Predicted)

Appearance

White to light yellow Solid

InChI

InChI=1S/C8H17NO/c10-7-1-2-8-3-5-9-6-4-8/h8-10H,1-7H2

InChIKey

DBIMLJDSPUCGGY-UHFFFAOYSA-N

SMILES

N1CCC(CCCO)CC1

EPA Substance Registry System

4-Piperidinepropanol (7037-49-2)

Safety Information

HazardClass 

IRRITANT

HS Code 

2933399990

piperidine-4-propanol Usage And Synthesis

Uses

4-(3-Hydroxypropyl)piperidine is used in the synthesis of G-protein coupled receptor (GPR119) agonists based on a bicyclic amine scaffold. Also used in the synthesis and antimicrobial activities of novel quinoline derivatives.

Uses

piperidine-4-propanol is used in the synthesis of G-protein coupled receptor (GPR119) agonists based on a bicyclic amine scaffold. Also used in the synthesis and antimicrobial activities of no vel quinoline derivatives.

Synthesis

Platinum(IV) oxide (1.45 g, 6.4 mmol) was added to a mixed solution of 4-pyridinepropanol (10.0 g, 72.89 mmol) in methanol (110 mL) and 32% hydrochloric acid (18 mL) under argon protection. The reaction mixture was stirred vigorously under low pressure hydrogen (8 kPa) for 46 hours. Upon completion of the reaction, most of the catalyst was removed by filtration, followed by distillation under reduced pressure to remove the volatile solvent. The oily residue obtained was dissolved in 15% NaOH aqueous solution (80 mL) and extracted with dichloromethane (first 150 mL, then 3 x 100 mL). The organic phases were combined, washed with deionized water (20 mL) and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and dried under vacuum to give 3-(4-piperidinyl)-1-propanol (10.3 g, 98% yield) as a white crystalline solid with a melting point of 58-60 °C. Thin layer chromatography (TLC) showed Rf = 0.2 (Expander: dichloromethane/methanol/28% ammonia = 50:10:1). Infrared spectroscopy (Nujol) showed characteristic absorption peaks located at 3290 cm?1 and 1320 cm?1. NMR hydrogen spectra (300 MHz, CD?OD) δ (ppm): 1.08-1.23 (m, 2H), 1.27-1.36 (m, 2H), 1.36-1.49 (m, 1H), 1.53-1.63 (m, 2H). 1.74 (br d, 2H, J≈13.4 Hz), 2.59 (dt, 2H, J=12.4, 2.6 Hz), 3.04 (td, 2H, J=12.4, 2.9 Hz), 3.56 (t, 2H, J=6.6 Hz). NMR carbon spectrum (75 MHz, CD?OD) δ (ppm): 31.5, 34.8, 35.2, 38.0, 47.9, 64.0. mass spectrum (ESI, MeOH) m/z (%): 287 (36) [2M+H]? , 144 (100) [M+H]? Molecular formula C?H??NO (molecular weight 143.2).

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 23, # 14, p. 3970 - 3990
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 16, p. 2537 - 2551
[3] Organic Letters, 2002, vol. 4, # 4, p. 549 - 552
[4] Tetrahedron, 1999, vol. 55, # 39, p. 11619 - 11639
[5] Journal of Polymer Science, 1959, vol. 40, p. 377,384

piperidine-4-propanol(7037-49-2)Related Product Information

• (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Cinchonine
• QUININE FORMATE
• SYROSINGOPINE
• RESCINNAMINE
• Cinchonidine
• QUINIDINE GLUCONATE
• Reserpine
• CINCHONIDINE SULFATE
• CINCHONINE SULFATE
• QUININE VALERATE
• TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
• 1-Piperidine-1-propanol,piperidine-1-propanol
• α,α-Diphenyl-1-piperidine-1-propanol
• (±)-2-Methyl-1-piperidine-1-propanol benzoate,(2R)-2-Methyl-1-piperidine-1-propanol benzoate
• α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidine-1-propanol
• α-Cyclopentyl-α-phenyl-1-piperidine-1-propanol
• Cevadine