1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- Chemical Properties

Boiling point:

613.0±55.0 °C(Predicted)

Density 

1.308±0.06 g/cm3(Predicted)

solubility 

DMSO: Sparingly soluble: 1-10 mg/ml

form 

Solid

pka

12.12±0.70(Predicted)

color 

White to off-white

1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- Usage And Synthesis

Uses

ZINC40099027 is a FAK activator. ZINC40099027 promotes FAK phosphorylation, inducing mucosal healing in murine models. ZINC40099027 can be used for Gastroduodenal ulcer disease research[1].

References

[1] Wang Q, et al. Discovery of Novel Small-Molecule FAK Activators Promoting Mucosal Healing. ACS Med Chem Lett. 2021 Feb 16;12(3):356-364. DOI:10.1021/acsmedchemlett.0c00311
[2] QINGGANG WANG. Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing[J]. Scientific Reports, 2019. DOI: 10.1038/s41598-019-51183-z

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