1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)- Chemical Properties

Boiling point:

479.2±45.0 °C(Predicted)

Density 

1.418±0.06 g/cm3(Predicted)

pka

10.83±0.10(Predicted)

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)- Usage And Synthesis

Uses

ZINC194100678 is a potent PAK1 inhibitor with an IC50 value of 8.37 μM. ZINC194100678 can inhibit MDA-MB-231 cell proliferation. ZINC194100678 can be used for researching anticancer[1].

IC 50

PAK1: 8.37 μM (IC₅₀)

References

[1] Zhang J, et al. Design, synthesis and biological evaluation of 1H-pyrazolo [3,4-d]pyrimidine derivatives as PAK1 inhibitors that trigger apoptosis, ER stress and anti-migration effect in MDA-MB-231 cells. Eur J Med Chem. 2020;194:112220. DOI:10.1016/j.ejmech.2020.112220

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