KARAKOLINE Chemical Properties

Melting point:

185-186℃ (acetone )

Boiling point:

540.2±50.0 °C(Predicted)

Density 

1.30±0.1 g/cm3 (20 ºC 760 Torr)

storage temp. 

2-8°C

form 

Solid

pka

13.80±0.70(Predicted)

color 

White to off-white

Safety Information

RTECS 

AR5569480

KARAKOLINE Usage And Synthesis

Description

A second atisine base found in the tubers of Aconitum karacolicum, the structure has been elucidated from chemical and spectroscopic data. Oxidation with KMn04 gives anhydroepoxykaracoline. The alkaloid furnishes a triacetyl deriva_x0002_tive which, after pyrolysis and hydrolysis, yields acetyldemethylisopyrokaracoline.

Uses

Karacoline is an Aconitane (A189875) derivative, which is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.

Definition

ChEBI: An organonitrogen heterocyclic compound that is aconitane bearing hydroxy groups at the 1alpha, 8, and 14alpha positions and substituted at on the nitrogen and at positions 4 and 16beta by ethyl, methyl, a d methoxy groups, respectively.

References

Sultankhodzhaev, Yunusov, Yunusov., Khim. Prir. Soedin., 9, 199 (1973)

KARAKOLINE(39089-30-0)Related Product Information

• ranaconitine
• Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)- , (1alpha,6alpha,14alpha,15alpha,16beta)-
• INDACONITINE
• Aconitine
• benzoylmesaconine
• Benzoylhypacoitine
• CRASSICAULINE A
• Acetylaconitine
• Benzoylhypacoitine
• 12-epi-Napelline
• benzoylaconine
• Mesaconitine
• Hypaconitine
• VILMORRIANINE C
• Bullatine B
• CHASMANINE
• KARAKOLINE
• VILMORRIANINE A