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Bullatine B

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Bullatine B Basic information

Product Name:
Bullatine B
Synonyms:
  • Bullatine B
  • Aconitane-1,8,14-triol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-, (1-alpha,6-alpha,14-alpha,16-beta)-
  • Dideacetyldelphisine
  • Xuan-wu 3
  • Neoline,Bullatine B
  • Aconitane-1,8,14-triol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-, (1α,6α,14α,16β)-
  • (3S,6S,6aS,7R,7aR,8S,9S,10S,11aR,12R,13R,14R)-1-ethyl-10,13-dimethoxy-3-(methoxymethyl)tetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocine-6,8,11a-triol
  • (3S,6S,7R,7aR,8S,9S,10S,11aR,12R,12aR,13R,14R)-1-Ethyl-10,13-dimethoxy-3-(methoxymethyl)tetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocine-6,8,11a-triol
CAS:
466-26-2
MF:
C24H39NO6
MW:
437.57
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
466-26-2.mol
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Bullatine B Chemical Properties

Melting point:
153-154 °C
Boiling point:
578.3±50.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Sparingly), Methanol (Very Slightly)
form 
Solid
pka
13.32±0.70(Predicted)
color 
White to Off-White
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Safety Information

Toxicity
LD50 intraperitoneal in mouse: 150mg/kg
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Bullatine B Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the tuberous roots of the northern aconite, the roots of Artemisia annua produced in various parts of Yunnan containing Artemisia annua methyl and ethylin, ethylin proved to be niaoulin.

Uses

Bullatine B is an aconitine-type alkaloid which exhibits antiarrhythmic properties.

in vivo

Neoline (10 mg/kg/day; sc; 10 days) alleviates oxaliplatin-induced peripheral neuropathy. Neoline inhibits paclitaxel- or partial sciatic nerve injury-induced allodynia in mice model[1].
Neoline (1-10 mg/kg; sc; single dose) shows antinociceptive effect and significantly increases the mechanical nociceptive threshold in diabetic mices[2].

Bullatine BSupplier

BioBioPha Co., Ltd.
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0871-65217109 13211707573;
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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cwb1@biopurify.cn
Chengdu Climax Biotech Co., Ltd.
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028-83311324 1278112614
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climaxbiotech@gmail.com
Shanghai Winherb Medical Technology Co., Ltd.
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021-38218169 13341702378
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winherb@126.com
Shanghai Ruji Biology Technology Co., Ltd.
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+86-21-65211385-8001 36031160
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sales@shruji.com