Scutellarin Chemical Properties

Melting point:

300～301℃

Boiling point:

891.6±65.0 °C(Predicted)

Density 

1.810±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO (Slightly), Methanol (Very Slightly, Sonicated)

pka

2.72±0.70(Predicted)

form 

Solid

color 

Light Yellow to Yellow

BRN 

71779

CAS DataBase Reference

27740-01-8(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29389090

Scutellarin Usage And Synthesis

Description

Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties. It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 μM, effects that can be blocked by the autophagy inhibitor HCQ . Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg. It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.

Uses

Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascular diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells.

Definition

ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of scutellarein.

Scutellarin(27740-01-8)Related Product Information

• Baicalin
• Baicalein
• SCUTELLAREIN
• Isoimperatorin
• Genistin
• Isoliquiritigenin
• 5,7-Dihydrox -4'-methoxyisoflavone
• FLAVONE
• APIGENIN-7-GLUCURONIDE
• Wogonoside
• Tetramethyl-O-scutellarin
• BAICALIN HYDRATE
• 3',5'-Dimethoxytricetin 7-O-β-D-glucopypranoside
• 7-HYDROXYFLAVONE-BETA-D-GLUCOSIDE
• BREVISCAPIN
• Scutellarin
• ERIGERON BREVISCAPUS SCUTELLARIN:>5%,DCQ:>5%