FLAVONE Chemical Properties

Melting point:

94-97 °C (lit.)

Boiling point:

185 °C / 1mmHg

Density 

1.1404 (rough estimate)

refractive index 

1.6600 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

>38.3 mg/mL in EtOH; >52.3 mg/mL in DMSO

form 

Crystalline Powder

color 

White

Water Solubility 

Soluble in acetone (25 mg/ml), methanol, alcohol, and chloroform. Insoluble in water.

Merck 

14,4092

BRN 

157598

LogP

3.560

CAS DataBase Reference

525-82-6(CAS DataBase Reference)

EPA Substance Registry System

Flavone (525-82-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

2

RTECS 

DJ3100630

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29329990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

FLAVONE Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

Flavone is a potentially useful biochemical for cytochrome P450 studies.

Definition

One of a group of flavonoid plant pigments existing as colorless needles, that are insoluble in water and melting at 100C. It fluoresces violet in concentrated sulfuric acid. It can be synthesized. Treatment with alcoholic alkali yields flavanone. The fla

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 689, 1957 DOI: 10.1021/ja01560a050
The Journal of Organic Chemistry, 44, p. 497, 1979 DOI: 10.1021/jo01318a005
Tetrahedron Letters, 31, p. 4073, 1990 DOI: 10.1016/S0040-4039(00)94503-9

Purification Methods

Dissolve it in dilute aqueous NaOH, filter and precipitate it by adding dilute (1:1) HCl. The process is repeated twice more, and the fluorescein is dried at 100o. Alternatively, it has been crystallised from acetone by allowing the solution to evaporate at 37o in an open beaker. It has also been recrystallised from EtOH and dried in a vacuum oven. [Beilstein 19 I 721, 19 II 248, 19 III/IV 2904, 19/8 V 456.]

FLAVONE(525-82-6)Related Product Information

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