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ORIENTIN

Basic information Safety Supplier Related

ORIENTIN Basic information

Product Name:
ORIENTIN
Synonyms:
  • 2-(3,4-Dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one
  • ORIDONIN (RG)
  • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-.beta.-D-glucopyranosyl-5,7-dihydroxy-
  • Aids026706
  • Aids-026706
  • 8-Glucosylluteolin
  • ORIENTIN
  • ORIENTINE
CAS:
28608-75-5
MF:
C21H20O11
MW:
448.38
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Aromatics, Glucuronides, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:
28608-75-5.mol
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ORIENTIN Chemical Properties

Melting point:
260-285°C
Boiling point:
816.1±65.0 °C(Predicted)
Density 
1.759±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
1 M NaOH: soluble1mg/mL, clear, yellow-orange
pka
6.24±0.40(Predicted)
form 
powder
color 
yellow
Stability:
Hygroscopic
LogP
1.580 (est)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
RTECS 
DJ3009300
HS Code 
29389090
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ORIENTIN Usage And Synthesis

Description

Orientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties. Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; ) radicals with an IC50 value of 316.21 μg/ml. It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC50 value of 11.7 μg/ml and a cytotoxic concentration (CC50) value of 375 μg/ml in Hep-2 cells. Orientin (5-40 μM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs). It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 μg/animal 12 hours after LPS administration.

Chemical Properties

Yellow powder

Uses

Orientin is a flavone, a chemical flavonoid compound. Orientin have been investigated for its anti-oxidant, antihypertensive and antihyperlipidemic effects.

Definition

ChEBI: A C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8.

ORIENTINSupplier

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