(S)-(-)-3-BENZYLOXY-1,2-PROPANEDIOL Chemical Properties

Melting point:

24-26 °C(lit.)

Boiling point:

261 °C(lit.)

alpha 

-5.5o (C=20% IN CHLOROFORM)

Density 

1.0966 (rough estimate)

refractive index 

-5.5 ° (C=20, CHCl3)

Flash point:

>230 °F

storage temp. 

Sealed in dry,2-8°C

pka

13.65±0.20(Predicted)

form 

powder to lump to clear liquid

color 

White or Colorless to Light yellow

optical activity

[α]20/D 5.5±0.5°, c = 20% in chloroform

BRN 

2415534

CAS DataBase Reference

17325-85-8(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

3-10

HS Code 

2905399590

MSDS

• Language:English Provider:SigmaAldrich

(S)-(-)-3-BENZYLOXY-1,2-PROPANEDIOL Usage And Synthesis

Chemical Properties

white to slightly yellow crystalline low melting

Uses

(S)-(-)-3-Benzyloxy-1,2-propanediol is a useful building block. It is used in the preparation of the nucleotide analog (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cystosine with antiviral activities. It is also used to synthesize cationic cardiolipin analogs with drug delivery systems such as transfection reagents.

Purification Methods

Purify the diol by repeated fractional distillation. [Baer et al. J Biol Chem 230 447 1958, Gigg & Gigg J Chem Soc C 1865 1967, Beilstein 6 IV 2247.]

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