SCUTELLAREIN Chemical Properties

Melting point:

330°C

Boiling point:

642.9±55.0 °C(Predicted)

Density 

1.654±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO: soluble1mg/mL, clear, greenish-yellow

form 

powder

pka

6.34±0.40(Predicted)

color 

yellow

InChIKey

JVXZRQGOGOXCEC-UHFFFAOYSA-N

LogP

2.540 (est)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29329990

SCUTELLAREIN Usage And Synthesis

Description

Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC₅₀s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM. In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.

Chemical Properties

Yellow solid

Uses

Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue.

Definition

ChEBI: Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.

SCUTELLAREIN(529-53-3)Related Product Information

• SCUTELLAREIN 7-O-GLUCURONIDE,Scutellarein 4'-methyl ether 7-glucuronide,Scutellarein 7-glucuronide
• MONOCROTALINE
• EUPATORIN-5-METHYL ETHER
• 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE
• SCUTELLAREIN
• 6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
• APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER
• Tangeretin
• 3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE
• SCUTELLAREIN TETRAMETHYL ETHER,SCUTELLAREIN TETRAMETHYL ETHER, (REAGENT GRADE),SCUTELLAREIN TETRAMETHYLETHER(RG)
• 3',4',5',5,6,7-HEXAMETHOXYFLAVONE
• 3,3',4',5,6,7-HEXAHYDROXYFLAVONE
• SCUTELLAREIN 6-METHYL ETHER
• HINOKIFLAVONE
• CASTICIN
• 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE
• 6-METHOXYLUTEOLIN
• Baicalein