6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Chemical Properties

Melting point:

280-281.5℃ (methanol )

Boiling point:

616.1±55.0 °C(Predicted)

Density 

1.483±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Acetone: soluble; Chloroform: soluble; DMSO: soluble

pka

6.31±0.40(Predicted)

form 

powder

color 

white to beige

Safety Information

WGK Germany 

3

RTECS 

DJ3011100

6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Usage And Synthesis

Definition

ChEBI: A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5, 3' and 4' respectively.

Biological Activity

Cirsiliol is a flavonoid th at displays anti-inflammatory, anti-oxidant, anti-proliferative, and anti-bacterial activities. Cirsiliol sensitizes non-small cell lung cancer cell lines (NSCLC) to radiation therapy. Cirsiliol inhibits epithelial-mesenchymal transition likely by induction of tumor-suppressive miR-34a, which suppresses Notch-1 expression NSCLC.

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