H-TYR-NH2 HCL Chemical Properties

Melting point:

153.5°C

Boiling point:

313.03°C (rough estimate)

Density 

1.1819 (rough estimate)

refractive index 

1.5373 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility 

DMF: 10mg/mL; DMSO: 10mg/mL; PBS (pH 7.2): 10mg/mL

form 

A solid

pka

9.97±0.15(Predicted)

Safety Information

WGK Germany 

3

MSDS

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H-TYR-NH2 HCL Usage And Synthesis

Description

L-Tyrosine amide is a tyrosine derivative and chiral ligand that has been used in the in vitro selection of DNA aptamers for the development of aptamer-based biosensors.

Chemical Properties

White to off-white powder

Uses

L-Tyrosinamide is a derivative of Tyrosine, is an amino acid amide[1].

Definition

ChEBI: An amino acid amide that is L-tyrosine in which the carboxy OH group is replaced by NH2.

Synthesis

General procedure for the synthesis of (S)-2-amino-3-(4-hydroxyphenyl)propionamide from L-tyrosine methyl ester hydrochloride: L-tyrosine methyl ester hydrochloride (1.16 g, 5 mmol) was added to a 50 mL reaction vessel with concentrated ammonia (40 mL), and the reaction was stirred for 4 hours at room temperature. Upon completion of the reaction, the ammonia was removed by rotary evaporation followed by rotary drying. The crude product was washed with anhydrous ethanol (20 mL x 2) followed by water. Finally, it was purified by column chromatography (silica gel, 200-300 mesh; unfolding agent ratio of ethyl acetate:methanol:ammonia = 300:10:15) to afford L-tyrosine amide in 86% yield.

References

[1] Vianini E, et al. In vitro selection of DNA aptamers that bind L-tyrosinamide. Bioorg Med Chem. 2001 Oct;9(10):2543-8. DOI:10.1016/s0968-0896(01)00054-2

H-TYR-NH2 HCL(4985-46-0)Related Product Information

• H-TYR-OBZL
• tert-Butyl L-tyrosinate
• L-Tyrosine benzyl ester p-toluenesulfonate
• L-Tyrosinol hydrochloride
• L-Tyrosine Ethyl Ester Hydrochloride
• H-TYR-GLY-GLY-OH
• Tyr-NH2 HCl,TYR-NH2·HCL 98+%,H-L-Tyr-NH2*HCl,H-TYR-NH2 HCL
• PUROMYCIN DIHYDROCHLORIDE
• L-TYROSINE HYDRAZIDE
• AC-TYR-NH2
• H-TYR-GLY-OH
• H-GLY-TYR-NH2
• H-GLY-TYR-NH2 HCL
• H-TYR-ALA-OH
• H-TYR-GLU-OH
• BZ-TYR-NH2
• AC-PHE-TYR-NH2
• Z-TYR-ALA-OH