Etomidate Chemical Properties

Melting point:

72-74°C

alpha 

D20 +66° (c = 1 in ethanol)

Boiling point:

160-162 °C(Press: 1 Torr)

Density 

1.11±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: >10 mg/mL

form 

powder

pka

pKa 4.24(H2O t=25.0) (Uncertain)

color 

white

Merck 

14,3881

CAS DataBase Reference

33125-97-2(CAS DataBase Reference)

NIST Chemistry Reference

Etomidate(33125-97-2)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

RTECS 

NI4021500

HazardClass 

9

PackingGroup 

III

HS Code 

29332900

Toxicity

LD50 in mice, rats (mg/kg): 29.5, 14.8-24.3 i.v. (Janssen)

MSDS

• Language:English Provider:Etomidate
• Language:English Provider:SigmaAldrich

Etomidate Usage And Synthesis

Description

Etomidate , ethyl (R)-(+)-1(α- methylbenzyl)-imidazole-5-carboxylate, Mr 224.28, is a white to yellowish crystalline or amorphous powder. It is insoluble in water at pH 7, but soluble in acidic aqueous solutions at pH<3. Etomidate is soluble in propylene glycol and readily soluble in alcohol.

Chemical Properties

Etomidate is a white crystalline powder. easily soluble in water, methanol, ethanol and propylene glycol, soluble in chloroform, insoluble in acetone, insoluble in ether. Its effects on the central nervous system is similar to barbiturates.

Originator

Hypnomidate,Janssen,W. Germany,1977

Uses

Etomidate is a GABAA receptors agonist with short-acting sedative, hypnotic, and general anesthetic properties. It is a unique drug used for induction of general anesthesia and sedation. It is also a hypnotic. Hypnotic effect of Etomidate is strong , and its efficacy is about 12 times higher than thiopental, it has no analgesic effect.

Definition

ChEBI: Etomidate is the ethyl ester of 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. It is an intravenous general anaesthetic with no analgesic activity. It has a role as an intravenous anaesthetic and a sedative. It is a member of imidazoles and an ethyl ester. It derives from a 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid.

Indications

Etomidate is administered intravenously as a short-acting anesthetic for the induction of lengthy anesthesia, especially for the induction of neuroleptanalgesia and inhalation anesthesia . Etomidate produces 3 – 5 min of sleep.

brand name

Amidate (Hospira);Hypnomidate concentrate;Hypnomidate injection;Hypromidate;Nalgol;Sibu.

Therapeutic Function

Hypnotic

World Health Organization (WHO)

Etomidate, a potent hypnotic agent, was introduced in 1977 for use as an intravenous anaesthetic. Its prolonged use can inhibit adrenal steroidogenesis and, following reports of reduced serum cortisol levels unresponsive to ACTH injection, the manufacturer suspended promotion of etomidate for sedation in intensive care in 1983. In 1985 regulatory action taken only in the United Kingdom further restricted use of the drug to induction of anaesthesia. Etomidate remains widely available and is currently registered for induction of anaesthesia in 34 countries and for maintenance of anaesthesia in 17 countries. It has never been registered for sedation.

Biological Functions

The pharmacological properties of etomidate (Amidate) are similar to those of the barbiturates, although its use may provide a greater margin of safety because of its limited effects on the cardiovascular and respiratory systems. Since it has a relatively short elimination halflife (t_1/2β = 2.9 hours), in addition to its use as an induction agent, etomidate has been used as a supplement to maintain anesthesia in some critically ill patients. Etomidate is rapidly hydrolyzed in the liver.

General Description

Etomidate is a carboxylated imidazole intended for the inductionof general anesthesia. It is marketed as the morepotent R (+) isomer. It is believed to exert its anestheticeffect via positive modulation of the GABAA receptor. Itis not water soluble and is available in the United States as a2-mg/mL solution containing 35% v/v propylene glycol andin Europe as a soybean oil and medium-chain triglyceridesformulation. The propylene glycol has been associatedwith moderate-to-severe pain on injection and irritation ofthe vascular tissue. A high incidence of skeletal musclemovements were noted in about 32% of patients followingetomidate injection. Case reports of seizures are also foundin the literature.

Biological Activity

Etomidate is a general anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β 2- and β 3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage.

Clinical Use

Etomidate should only beused for induction of anesthesia when the cardiac benefitsoutweigh the risks associated with adrenal insufficiency.Etomidate is quickly distributed throughout most organsin the body after intravenous administration and the tissueconcentrations equal and sometimes exceed the plasmaconcentrations. The lipid solubility of the drug allows it torapidly penetrate into the brain with peak concentrationsoccurring within 1 minute of administration. Etomidate israpidly metabolized in the plasma and liver via esterases.About 75% of the drug is eliminated in the urine as the inactiveester hydrolyzed carboxylic acid.

Side effects

Etomidate may cause pain on injection and may produce myoclonic muscle movements in approximately 40% of patients during its use as an induction anesthetic. In addition, etomidate can suppress the adrenocortical response to stress, an effect that may last up to 10 hours.

Synthesis

The preparation of etomidate involves a modification of Jones’ synthesis: α- phenylethylamine is alkylated with ethyl chloroacetate to the N-(α-phenylethyl)-glycine ester, whose NH group is formylated. This product is condensed with methyl formate and cyclized withHCl-KSCNto yield ethyl 2-mercapto-1-(α- methylbenzyl)-5-imidazolecarboxylate, which is then oxidatively desulfurized . The (R) isomer is obtained by separating the racemic acid with (R)-(+)-1-phenylethylamine.

Veterinary Drugs and Treatments

Etomidate may be useful as an alternative to thiopental or propofol for anesthetic induction in small animals, particularly in patients with preexisting cardiac dysfunction, head trauma, or that are critically ill.

Drug interactions

Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: enhanced hypotensive effect.
Antihypertensives: enhanced hypotensive effect.
Antidepressants: avoid MAOIs for 2 weeks before surgery; increased risk of arrhythmias and hypotension with tricyclics.
Antipsychotics: enhanced hypotensive effect.

Metabolism

Etomidate is hydrolyzed by hepatic esterases to the corresponding inactive carboxylic acid, with subsequent renal and biliary excretion terminating its action. Its apparent elimination half-life is approximately 5 to 6 hours, with a volume of distribution of 5 to 7 L/kg. Changes in hepatic blood flow or hepatic metabolism will have only moderate effects on etomidate disposition. Concerns regarding the ability of etomidate to precipitate myoclonic jerks and inhibit adrenal steroid synthesis have been reported.

storage

Room temperature

Mode of action

The exact mechanism of action of etomidate is unknown. It is felt to induce sedation by interaction with GABA receptors. and likely enhances the activity of a-aminobutyric acid. However, it is not structurally related to benzodiazepines or to barbiturates. Of significantnote, etomidate exhibits no analgesic properties.

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