PE 22-28
PE 22-28 Basic information
- Product Name:
- PE 22-28
- Synonyms:
-
- L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-
- (2S,5S,11S,14S,17S)-11-((1H-Indol-3-yl)methyl)-20-amino-2-(3-guanidinopropyl)-14-(hydroxymethyl)-5-isobutyl-17-isopropyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazaicosan-1-oic acid
- PE 22-28
- CAS:
- 1801959-12-5
- MF:
- C35H55N11O9
- MW:
- 773.88
- Mol File:
- 1801959-12-5.mol
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PE 22-28 Chemical Properties
- Density
- 1.44±0.1 g/cm3(Predicted)
- pka
- 3.34±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Gly-Val-Ser-Trp-Gly-Leu-Arg
- InChIKey
- CMNBQRXBBJQIOA-YIHYGEMESA-N
- SMILES
- C(O)(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)CN
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PE 22-28 Usage And Synthesis
Uses
PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1].
in vivo
PE 22-28 (i.p.; 3.0μg/kg) shows antidepressant property[1].
| Animal Model: | Nave male C57Bl/6J mice[1] |
| Dosage: | 3.0μg/kg |
| Administration: | Intraperitoneal |
| Result: | Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration. |
References
[1] Alaeddine Djillani, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Front Pharmacol. 2017 Sep 12;8:643. DOI:10.3389/fphar.2017.00643
PE 22-28Supplier
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070 13913916777;
- info@chemlin.com.cn
Hangzhou J&H Chemical Co., Ltd.
- Tel
- 0571-87396432
- sales@jhechem.com
Shanghai Haozhixiang Biotechnology Co., Ltd
- Tel
- 526763801 13301653310
- 526763801@qq.com
Chengdu Youngshe Chemical Co., Ltd.
- Tel
- +86-17380623303
- Caroline@youngshechem.com
Hangzhou Peptidego Biotech Co.,Ltd.
- Tel
- 0571-87213919
- Eric@peptidego.com