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2-Iodophenylacetic acid

Basic information Safety Supplier Related

2-Iodophenylacetic acid Basic information

Product Name:
2-Iodophenylacetic acid
Synonyms:
  • RARECHEM AL BO 1302
  • O-IODOPHENYLACETIC ACID
  • 2-IODOPHENYLACETIC ACID
  • 2-(2-IODOPHENYL)ACETIC ACID
  • BENZENEACETIC ACID, 2-IODO-
  • 2-Iodo-benzeneacetic acid
  • 2-IODOPHENYLACETIC ACID, 98+%
  • 2-IODOPHENYLACETIC ACID, 97+%
CAS:
18698-96-9
MF:
C8H7IO2
MW:
262.04
EINECS:
629-244-1
Product Categories:
  • C8
  • Carbonyl Compounds
  • Aromatic Phenylacetic Acids and Derivatives
  • Phenylacetic acid
  • Miscellaneous
  • Carboxylic Acids
  • bc0001
Mol File:
18698-96-9.mol
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2-Iodophenylacetic acid Chemical Properties

Melting point:
116-119 °C (lit.)
Boiling point:
344.5±17.0 °C(Predicted)
Density 
1.885±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Powder
pka
pK1:4.038 (25°C)
color 
Cream
Sensitive 
Light Sensitive
BRN 
2086800
CAS DataBase Reference
18698-96-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37
WGK Germany 
3
Hazard Note 
Irritant/Light Sensitive
HazardClass 
IRRITANT, LIGHT SENSITIVE
HS Code 
29163990

MSDS

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2-Iodophenylacetic acid Usage And Synthesis

Chemical Properties

Cream powder

Uses

2-Iodophenylacetic acid is a synthetic intermediate that is widely used in the chemical, pharmaceutical and cosmetic industries. 2-Iodophenylacetic acid is also used as a reagent to synthesize Cepharanone B, a natural and potentially antineoplastic aristolactam that is found in Piper longum (a medicinal plant native to India).

Application

2-Iodophenylacetic acid may be used in the preparation of:
2-iodophenylacetyl chloride
3,4-dimethoxyphenyl 2-iodophenylacetate
N-{2-[2-(2-iodophenyl)-acetylamino]-ethyl}-2-(3,4- dichlorophenyl)-acetamide

Preparation

synthesis of 2-Iodophenylacetic acid: The anthranilic acid solution was acidified with sulfuric acid to pH = 1 followed by a diazotization reaction. The diazonium was added dropwise to the potassium iodide-sulfuric acid solution (3.5 g KI, 1.0 mL concentrated H2SO4, 5 mL water) preheated to 60-70 °C, stirred for 30 min, placed overnight, and filtered to obtain the product. Recrystallization with 50% ethanol aqueous solution gave 3.83 g of 2-iodophenylacetic acid, the yield was 73% (calculated as o-nitrophenylacetic acid), and the melting point was 113-115 °C (117 °C reported in the literature).

General Description

2-Iodophenylacetic acid is a substituted acetic acid that can be prepared from 2-iodobenzyl cyanide. It undergoes palladium-catalyzed reaction with allenes to form 1,3-butadienes. 2-Iodophenylacetic acid also undergoes photolysis in carbon tetrachloride to form the corresponding chloro compound.

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