2-Iodophenylacetic acid Chemical Properties

Melting point:

116-119 °C (lit.)

Boiling point:

344.5±17.0 °C(Predicted)

Density 

1.885±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Powder

pka

pK1:4.038 (25°C)

color 

Cream

Sensitive 

Light Sensitive

BRN 

2086800

CAS DataBase Reference

18698-96-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37

WGK Germany 

3

Hazard Note 

Irritant/Light Sensitive

HazardClass 

IRRITANT, LIGHT SENSITIVE

HS Code 

29163990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Iodophenylacetic acid Usage And Synthesis

Chemical Properties

Cream powder

Uses

2-Iodophenylacetic acid is a synthetic intermediate that is widely used in the chemical, pharmaceutical and cosmetic industries. 2-Iodophenylacetic acid is also used as a reagent to synthesize Cepharanone B, a natural and potentially antineoplastic aristolactam that is found in Piper longum (a medicinal plant native to India).

Application

2-Iodophenylacetic acid may be used in the preparation of:
2-iodophenylacetyl chloride
3,4-dimethoxyphenyl 2-iodophenylacetate
N-{2-[2-(2-iodophenyl)-acetylamino]-ethyl}-2-(3,4- dichlorophenyl)-acetamide

Preparation

synthesis of 2-Iodophenylacetic acid: The anthranilic acid solution was acidified with sulfuric acid to pH = 1 followed by a diazotization reaction. The diazonium was added dropwise to the potassium iodide-sulfuric acid solution (3.5 g KI, 1.0 mL concentrated H2SO4, 5 mL water) preheated to 60-70 °C, stirred for 30 min, placed overnight, and filtered to obtain the product. Recrystallization with 50% ethanol aqueous solution gave 3.83 g of 2-iodophenylacetic acid, the yield was 73% (calculated as o-nitrophenylacetic acid), and the melting point was 113-115 °C (117 °C reported in the literature).

General Description

2-Iodophenylacetic acid is a substituted acetic acid that can be prepared from 2-iodobenzyl cyanide. It undergoes palladium-catalyzed reaction with allenes to form 1,3-butadienes. 2-Iodophenylacetic acid also undergoes photolysis in carbon tetrachloride to form the corresponding chloro compound.

2-Iodophenylacetic acid(18698-96-9)Related Product Information

• 2'-Iodoacetophenone
• (Diacetoxyiodo)benzene
• Ethyl acetate
• 1,4-Diiodobenzene
• 1,2-Diiodobenzene
• Citric acid
• Ascoric Acid
• Phenylacetic acid
• Peroxyacetic acid
• Chloroacetic acid
• 4-Iodophenoxyacetic acid
• Iodobenzene
• 4-IODOPHENYLACETIC ACID,4-IODOPHENYLACETIC ACID
• 4-IODPHENYLACETIC ACID METHYL ESTER
• M-IODOPHENYLACETIC ACID,M-IODOPHENYLACETIC ACID,3-IODOPHENYLACETIC ACID,3-IODOPHENYLACETIC ACID
• 4-Hydroxy-3,5-diiodophenylacetic acid
• 4-IODOPHENYLACETIC ACID ETHYL ESTER,4-IODOPHENYLACETIC ACID ETHYL ESTER
• 2-Iodophenylacetic acid