Zearalenone Basic information
- Product Name:
- Product Categories:
- Intermediates & Fine Chemicals
- Isotope Labeled Compounds
- Estrogen ModulatorsCell Signaling and Neuroscience
- MoldCancer Research
- CRM&Matrix RMBiotoxins
- NeatApplication CRMs
- Cancer Research
- Chemopreventive Agents
- Toxins and Venoms
- Tumor Growth Regulation
- Aromatic Ketones (substituted)
- Chiral Reagents
- Food and Agriculture CRM
- Mol File:
Zearalenone Chemical Properties
- Melting point:
- 25546 -170.5° (c = 1.0 in CH3OH)
- Boiling point:
- 377.53°C (rough estimate)
- 1.1270 (rough estimate)
- refractive index
- 1.6120 (estimate)
- Flash point:
- 6 °C
- storage temp.
- CAS DataBase Reference
- 17924-92-4(CAS DataBase Reference)
- EPA Substance Registry System
- Zearalenone (17924-92-4)
- Hazard Codes
- Risk Statements
- Safety Statements
- UN 3261 8/PG 2
- WGK Germany
- HS Code
- Hazardous Substances Data
- 17924-92-4(Hazardous Substances Data)
- Language:English Provider:[S-(E)]-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
- Language:English Provider:SigmaAldrich
Zearalenone Usage And Synthesis
Zearalenone is a resorcylic acid lactone produced by a number of Fusarium sp.. Zearalenone acts as a non-steroidal estrogen, binding to estrogen receptor and is uterotropic. Zearalenone induces reproductive problems in animals and, in some animal models, is thought to be a primary initiator of hepatic tumours. In vivo, zearalenone undergoes metabolic reduction to the more estrogenic zearalenol. Contamination of grains, notably maize, by Fusarium species gives rise to high levels of zearalenone and is regarded as an important food quality issue for both humans and animal health.
A phytoestrogenic mycotoxin and ER activator
Estrogenic mycotoxin produced by Fusarium fungi commonly found in grains. One of a group of compounds known as resorcylic acid lactones
ChEBI: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
White microcrystals or white powder.
Air & Water Reactions
Zearalenone may be sensitive to prolonged exposure to air. Insoluble in water.
Zearalenone is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Zearalenone may be incompatible with alkalis.
Flash point data for Zearalenone are not available. Zearalenone is probably combustible.
Zearalenone, a fungal mycotoxin produced by Fusarium, binds the estrogen receptor (ER) and is uterotropic in the newborn rat. It is a common contaminant in cereal grain used for animal and human food, and exerts an estrogenic activity that modulates/disrupts endocrine function in animals and possibly humans.
When zearalenone is subjected to microbial transformation by a fungus, Gliocladium roseum, it is converted to a 1 : 1 mixture of 1-(3,5-dihydroxyphenyl)- 10 0 -hydroxy-1-undecen-6'-one and 1-(3,5- dihydroxyphenyl)-6'-hydroxy-1-undecen-10'-one.
- 177-54423994 17754423994
- 028-85370565-229 18080489829
- 010-62971590 18548936886
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