toddalolactone
toddalolactone Basic information
- Product Name:
- toddalolactone
- Synonyms:
-
- toddalolactone
- 6-(2,3-Dihydroxy-3-methylbutyl)-5,7-dimethoxy-2H-1-benzopyran-2-one
- Toddaline
- (+)-Toddalolactone
- 6-[(2R)-2,3-dihydroxy-3-methyl-butyl]-5,7-dimethoxy-chromen-2-one
- 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one
- 6-[(2R)-2,3-dihydroxy-3-methyl-butyl]-5,7-dimethoxy-coumarin
- Toddaloactone
- CAS:
- 483-90-9
- MF:
- C16H20O6
- MW:
- 308.33
- Mol File:
- 483-90-9.mol
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toddalolactone Chemical Properties
- Melting point:
- 269-270°C
- Boiling point:
- 530.0±50.0 °C(Predicted)
- Density
- 1.269±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 14.39±0.20(Predicted)
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toddalolactone Usage And Synthesis
Description
Toddalia aculeata Pers. (Rutaceae) contains, in addition to Berberine (q.v.), two closely related alkaloids. This particular base forms colourless crystals from CHC13 and is characterized as the hydrochloride monohydrate, m.p. 205-6°C; nitrate, yellow needles, m.p. 239° C (dec.) and the picrate, glancing needles, m.p. 237-8°C. Two methoxyl groups and a methylimino group have been shown to be present.
Uses
Toddalolactone is a prenylated coumarin which acts as a natural phosphodiesterase-4 inhibitor. Antiplasmodial and larvicidal agent.
References
Dey, Pillay., Arch. Pharm., 271,477 (1933)
Dey et al., Ind. J. Med. Res., 22,765 (1935)
Lobstein, Hesse., Bull. Sci. Pharmacol., 38, 157 (1931)
toddalolactoneSupplier
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