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salvigenin

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salvigenin Basic information

Product Name:
salvigenin
Synonyms:
  • 5-Hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
  • 4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-
  • 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
  • Salvigenin,inhibit,Apoptosis,immunomodulatory,ROS Kinase,Autophagy,Inhibitor,neuroprotective,antioxidant
  • Salvigenin Salvigenin
  • Salvigenin, 10 mM in DMSO
CAS:
19103-54-9
MF:
C18H16O6
MW:
328.32
Product Categories:
  • Tetra-substituted Flavones
Mol File:
19103-54-9.mol
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salvigenin Chemical Properties

Melting point:
188 °C
Boiling point:
535.9±50.0 °C(Predicted)
Density 
1.314±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
pka
6.33±0.40(Predicted)
color 
Yellow
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salvigenin Usage And Synthesis

Uses

Salvigenin is a neuroprotective agent used in the treatment of neurodegenerative diseases acting through oxidative stress on cells.

Definition

ChEBI: Salvigenin is a trimethoxyflavone that is scutellarein in which the hydroxy groups at positions 4', 6, and 7 are replaced by methoxy groups. It has a role as an autophagy inducer, an apoptosis inhibitor, an antilipemic drug, an immunomodulator, an antineoplastic agent, a neuroprotective agent, a hypoglycemic agent and a plant metabolite. It is a trimethoxyflavone and a monohydroxyflavone. It is functionally related to a scutellarein.

in vivo

Salvigenin (0-9.68 μg/mouse/day; i.p.; 4 or 12 days) shows antitumor and immunomodulatory effects on tumor bearing mice[2].

Animal Model:MCF-7 cell bearing inbred female Balb/c mice, aged from six to eight weeks[2]
Dosage:3.65, 5.85 and 9.68 μg/mouse/day for four days or 12 days
Administration:Intraperitoneal injection
Result:Showed a significant increase in DTH response in a dose-dependent manner. Significantly decreased the rate of tumor growth, increased lymphocyte proliferation index, increased the level of IFN-γ and decreased IL-4 production. Exhibited a significant decrease of the splenic CD4+CD25+Foxp3+ T lymphocytes.

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