cynaropicrin Chemical Properties

Boiling point:

566.2±50.0 °C(Predicted)

Density 

1.28±0.1 g/cm3 (20 ºC 760 Torr)

storage temp. 

-20°C, protect from light

solubility 

DMSO:50.0(Max Conc. mg/mL);144.35(Max Conc. mM)

pka

13.52±0.10(Predicted)

form 

Oil

color 

Off-white to light yellow

LogP

1.340 (est)

cynaropicrin Usage And Synthesis

Uses

Cynaropicrin can inhibit lipopolysaccharide-induced TNF-α release from either murine or human macrophage cells in a dose-dependent manner with the IC50 values of 8.24 and 3.18 μM, respectively. It can also inhibit the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

Definition

ChEBI: Cynaropicrin is a sesquiterpene lactone.

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