Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Basic information
- Product Name:
- Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
- Synonyms:
-
- Pulsatilla saponin D (SB365)
- Pulsatilla Saponin D (90%)
- Olean-12-en-28-oic acid,3-[[O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl]oxy]-23-hydroxy-, (3b,4a)-
- Pulsatilla saponin D 68027-15-6
- Pulsatilla saponin D, BR
- Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β,4α)-
- Hederagenin 3-O-α-L-rhamnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
- Pulsatilla saponin D, 10 mM in DMSO
- CAS:
- 68027-15-6
- MF:
- C47H76O17
- MW:
- 913.09614
- EINECS:
- 211-708-6
- Product Categories:
-
- reagent
- standard substance
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 68027-15-6.mol
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Chemical Properties
- Melting point:
- 239-241℃
- Boiling point:
- 997.6±65.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Methanol (Slightly), Pyridine
- pka
- 4.63±0.70(Predicted)
- form
- Solid
- color
- White to Light Beige
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Usage And Synthesis
Description
Pulsatilla saponin D is an oleanane-type saponin that has been found in P. koreana and has anticancer activity. It is cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cells (EC50s = 11.25, 13.17, 3.04, and 11.86 μM, respectively). Pulsatilla saponin D (6 mg/kg per day) reduces tumor volume in a murine Lewis lung carcinoma model.
Chemical Properties
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Pulsatilla chinensis.
Uses
Pulsatilla Saponin D shows antiangiogenic and antitumor activity.
Definition
ChEBI: Pulsatilla saponin D is a triterpenoid. It has a role as a metabolite.
in vivo
Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model[4].
| Animal Model: | 2x2x2 mm3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice[4]. |
| Dosage: | 6.4 mg/kg. |
| Administration: | Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day. |
| Result: | Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). |
References
[1] SEONG-CHEOL BANG. Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship.[J]. Chemical & pharmaceutical bulletin, 2005, 53 11: 1451-1454. DOI: 10.1248/cpb.53.1451
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranosideSupplier
- Tel
- 025-83697070
- info@chemlin.com.cn
- Tel
- +86-028-82633397 18982077548
- cwb1@biopurify.cn
- Tel
- 025-84430028 13815430202
- sale02@cqherb.com
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- 021-58955995
- sales@medchemexpress.cn