Hederacolchiside A1
Hederacolchiside A1 Basic information
- Product Name:
- Hederacolchiside A1
- Synonyms:
-
- Hederacolchiside A1
- HEDERACOLCHISIDE A1;
- Raddeanoside R13
- Olean-12-en-28-oicacid, 3-[(O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl)oxy]-, (3b)-
- Oleanolic acid-3-O-β-D-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-]-α-L-arabinopyranoside，Hederacolchiside A1
- Olean-12-en-28-oic acid, 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl)oxy]-, (3β)-
- Hederacolchiside A1 USP/EP/BP
- Oleanolic acid-3-O-β-D-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)--α-L-arabinopyranoside，Hederacolchiside A1
- CAS:
- 106577-39-3
- MF:
- C47H76O16
- MW:
- 897.1
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- reagent
- standard substance
- Triterpenoids
- Mol File:
- 106577-39-3.mol
Hederacolchiside A1 Chemical Properties
- Melting point:
- 253-255℃ (methanol , water )
- Boiling point:
- 967.2±65.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in DMSO
- pka
- 4?+-.0.70(Predicted)
- form
- Solid
- color
- White to off-white
Hederacolchiside A1 Usage And Synthesis
Uses
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].
in vivo
hederacolchiside A1 (3.0, 4.5, and 6.0?mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1].
Hederacolchiside A1 (3.25, 7.5, and 15.0?mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells[1].
IC 50
Schistosome; PI3K; mTOR
References
[1] Yan-Er Wang, et al. Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Chinese Herbal Medicines.Volume 10, Issue 2, April 2018, Pages 215-222
[2] Kang N, et al. Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis. Molecules. 2018 Jun 13;23(6). DOI:10.3390/molecules23061431
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Hederacolchiside A1(106577-39-3)Related Product Information
- V
- Pulchinenoside B
- Scabioside C
- Lup-20(29)-en-28-oic acid, 3-[β-D-glucopyranosyl(1→4)[a-L-rhaMnopyranosyl) (1→2)-a -L-arabinopyranosyl]oxy], (3β,4a)-)
- Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
- V
- Hederacolchiside E
- PULCHINENOSIDE B4
- Anemoside A3 Pulchinenoside A3