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liriodenine

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liriodenine Basic information

Product Name:
liriodenine
Synonyms:
  • Iiriodenine
  • liriodenine
  • 8H-Benzo[G]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one
  • Micheline b
  • Noraporphin-7-one, 4,5,6,6A-tetradehydro-1,2-(methylenedioxy)-
  • Nsc93681
  • Oxoushinsunin
  • Oxoushinsunine
CAS:
475-75-2
MF:
C17H9NO3
MW:
275.26
Mol File:
475-75-2.mol
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liriodenine Chemical Properties

Melting point:
282°C
Boiling point:
531.0±19.0 °C(Predicted)
Density 
1.501±0.06 g/cm3(Predicted)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
pka
2.67±0.20(Predicted)
color 
Yellow
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liriodenine Usage And Synthesis

Description

Isolated from the heartwood extract of Liriodendron tulip/era, this base may be purified by crystallization from CHCI3. It contains one methylenedioxy group and a keto group, forming a crystalline oxime, m.p. 271°C. The structure has been confirmed by synthesis, the synthetic alkaloid having a higher melting point of 287°C.

Uses

Liriodenine is an isoquinoline alkaloid found in extracts of medicinal Asian vegetation such as Michelia alba and Liriodendron chinense.

Definition

ChEBI: An oxoaporphine alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2. It is isolated from Annona glabra and has been shown to exhibit antimicrobial and cytotoxic activities.

target

p53 | Caspase | Bcl-2/Bax | Sodium Channel | Potassium Channel | Topoisomerase | cAMP

References

Buchanan, Dickey.,J. Org. Chern., 25, 1389 (1960)
Taylor., Tetrahedron, 14,42 (1961)

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